PLA2G5

Gene Symbol PLA2G5
Entrez Gene 5322
Alt Symbol FRFB, GV-PLA2, PLA2-10, hVPLA(2)
Species Human
Gene Type protein-coding
Description phospholipase A2, group V
Other Description Ca2+-dependent phospholipase A2|calcium-dependent phospholipase A2|phosphatidylcholine 2-acylhydrolase 5
Swissprots Q8N435 P39877
Accessions AAR92480 EAW94911 EAW94912 EAW94913 P39877 AK097693 BAG53516 AV709457 BC036792 AAH36792 BM684907 BM705479 BX648966 U03090 AAC28886 XM_005245891 XP_005245948 XM_005245892 XP_005245949 XM_005245893 XP_005245950 XM_006710696 XP_006710759 XM_011541584 XP_011539886 XM_011541585 XP_011539887 XM_011541586 XP_011539888 XM_011541587 XP_011539889 XM_011541588 XP_011539890 XM_011541589 XP_011539891 XM_011541590 XP_011539892 XM_011541591 XP_011539893 XM_011541592 XP_011539894 NM_000929 NP_000920
Function PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle.
Subcellular Location Secreted.
Tissue Specificity Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level). {ECO:0000269|PubMed:22137173}.
Top Pathways Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism

Panoply™ Human PLA2G5 Knockdown Stable Cell Line - CSC-DC011877 from Creative biogene

Category Cell Line
Species Human
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