PLA2G5
| Gene Symbol | PLA2G5 |
|---|---|
| Entrez Gene | 5322 |
| Alt Symbol | FRFB, GV-PLA2, PLA2-10, hVPLA(2) |
| Species | Human |
| Gene Type | protein-coding |
| Description | phospholipase A2, group V |
| Other Description | Ca2+-dependent phospholipase A2|calcium-dependent phospholipase A2|phosphatidylcholine 2-acylhydrolase 5 |
| Swissprots | Q8N435 P39877 |
| Accessions | AAR92480 EAW94911 EAW94912 EAW94913 P39877 AK097693 BAG53516 AV709457 BC036792 AAH36792 BM684907 BM705479 BX648966 U03090 AAC28886 XM_005245891 XP_005245948 XM_005245892 XP_005245949 XM_005245893 XP_005245950 XM_006710696 XP_006710759 XM_011541584 XP_011539886 XM_011541585 XP_011539887 XM_011541586 XP_011539888 XM_011541587 XP_011539889 XM_011541588 XP_011539890 XM_011541589 XP_011539891 XM_011541590 XP_011539892 XM_011541591 XP_011539893 XM_011541592 XP_011539894 NM_000929 NP_000920 |
| Function | PA2 catalyzes the calcium-dependent hydrolysis of the 2- acyl groups in 3-sn-phosphoglycerides. This isozyme hydrolyzes more efficiently L-alpha-1-palmitoyl-2-oleoyl phosphatidylcholine than L-alpha-1-palmitoyl-2-arachidonyl phosphatidylcholine, L- alpha-1-palmitoyl-2-arachidonyl phosphatidylethanolamine, or L- alpha-1-stearoyl-2-arachidonyl phosphatidylinositol. May be involved in the production of lung surfactant, the remodeling or regulation of cardiac muscle. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Heart, placenta and less abundantly, in lung. Detected in the outer and inner plexiform layers of the retina (at protein level). {ECO:0000269|PubMed:22137173}. |
| Top Pathways | Vascular smooth muscle contraction, Pancreatic secretion, Fat digestion and absorption, Ether lipid metabolism, Glycerophospholipid metabolism |
group V PLA 2 CRISPR/Cas9 KO Plasmid (h) - sc-409663 from Santa Cruz Biotechnology
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group V PLA 2 HDR Plasmid (h) - sc-409663-HDR from Santa Cruz Biotechnology
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group V PLA 2 Double Nickase Plasmid (h) - sc-409663-NIC from Santa Cruz Biotechnology
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group V PLA 2 Double Nickase Plasmid (h2) - sc-409663-NIC-2 from Santa Cruz Biotechnology
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group V PLA 2 CRISPR Activation Plasmid (h) - sc-409663-ACT from Santa Cruz Biotechnology
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group V PLA 2 CRISPR Activation Plasmid (h2) - sc-409663-ACT-2 from Santa Cruz Biotechnology
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group V PLA 2 Lentiviral Activation Particles (h) - sc-409663-LAC from Santa Cruz Biotechnology
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group V PLA 2 Lentiviral Activation Particles (h2) - sc-409663-LAC-2 from Santa Cruz Biotechnology
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group V PLA 2 siRNA (h) - sc-44023 from Santa Cruz Biotechnology
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group V PLA 2 shRNA Plasmid (h) - sc-44023-SH from Santa Cruz Biotechnology
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group V PLA 2 shRNA (h) Lentiviral Particles - sc-44023-V from Santa Cruz Biotechnology
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Secretory phospholipase A2 Type V RNAi - H00005322-R01 from Novus Biologicals
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MISSION® esiRNA - EHU050591 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN16900 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND16900 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08671 from Sigma-Aldrich
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PLA2G5 siRNA (Human) - CRH3563 from Cohesion Biosciences
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shRNA set against Human PLA2G5 (NM_000929.2) - SHH376880 from Creative biogene
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shRNA set against Human PLA2G5(NM_000929.2) - SHR118096 from Creative biogene
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Human PLA2G5 siRNA - orb264065 from Biorbyt
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PLA2G5 shRNA Plasmid (Human) - CHH3563 from Cohesion Biosciences
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PLA2G5 miRNA 3'UTR clone - MiUTR1H-07963 from Creative biogene
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