MAN1B1

Gene Symbol MAN1B1
Entrez Gene 11253
Alt Symbol ERMAN1, MANA-ER, MRT15
Species Human
Gene Type protein-coding
Description mannosidase, alpha, class 1B, member 1
Other Description ER alpha 1,2-mannosidase|Man9GlcNAc2-specific processing alpha-mannosidase|endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase|endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1
Swissprots Q9Y5K7 Q9BRS9 Q5VSG3 Q9UKM7
Accessions EAW88345 EAW88346 EAW88347 Q9UKM7 AB209276 BAD92513 AF145732 AAD45504 AF148509 AAF03215 AI312031 AK074559 BAC11060 AK074699 BAG51987 AK094878 AK126926 AK127005 AK128033 AK128257 BAG54653 AK128341 BAG54664 AK130143 AK298480 BAG60691 AK299043 BAG61117 AK309808 AK315797 AL110221 CAB53680 AY358465 AAQ88830 BC002953 AAH02953 BC006079 AAH06079 BE731944 BM848429 BQ448144 CR749534 CAH18340 DA763005 DQ891861 ABM82787 DQ895050 ABM85976 XM_006716945 XP_006717008 NM_016219 NP_057303 NR_045720 NR_045721
Function Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). {ECO:0000269|PubMed:12090241, ECO:0000269|PubMed:18003979}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10409699}; Single-pass type II membrane protein {ECO:0000269|PubMed:10409699}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10409699, ECO:0000269|PubMed:10521544}.
Top Pathways N-Glycan biosynthesis, Protein processing in endoplasmic reticulum

MAN1B1 (E-10) - sc-393145 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
MAN1B1 (E-10): sc-393145. Western blot analysis of MAN1B1 expression in A-431 (A), Hep G2 (B), LNCaP (C), HeLa (D) and NTERA-2 cl.D1 (E) whole cell lysates.

MAN1B1 (D-14) - sc-104975 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

MAN1B1 (30-Y) - sc-100543 from Santa Cruz Biotechnology

Prices $295.00
Sizes 100 µg/ml
Host Mouse
Clonality Monoclonal
MAN1B1 (30-Y): sc-100543. Western blot analysis of MAN1B1 expression in Hep G2 whole cell lysate.

MAN1B1 (H-187) - sc-366923 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
MAN1B1 (H-187): sc-366923. Western blot analysis of MAN1B1 expression in A-431 whole cell lysate.

Anti-MAN1B1 antibody - ab95975 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-MAN1B1 antibody (ab95975) at 1/1000 dilution + HeLa whole cell lysate at 30 µg

Anti-MAN1B1 antibody - ab56931 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
MAN1B1 antibody (ab56931) used in immunohistochemistry at 3ug/ml on formalin fixed and paraffin embedded human stomach.

Anti-MAN1B1 Antibody (clone 6B1) - LS-C105112 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6B1
MAN1B1 monoclonal antibody (M01), clone 6B1 Western blot of MAN1B1 expression in A-431.

Anti-MAN1B1 Antibody (aa414-699) - LS-C185745 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded SCC25 xenograft using MAN1B1 antibody at 1:100 dilution.

Anti-MAN1B1 Antibody (clone 3C2, DY488) - LS-C181980 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

Anti-MAN1B1 Antibody (clone 3C2, DY650) - LS-C181979 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

Anti-MAN1B1 Antibody (clone 3C2, HRP) - LS-C181981 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

Anti-MAN1B1 Antibody (clone 3C2, Biotin) - LS-C181978 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

Anti-MAN1B1 Antibody (clone 3C2, DY550) - LS-C181982 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

Anti-MAN1B1 Antibody (aa112-212, Azide-free) - LS-C327814 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

ERManI Antibody (3C2) - NBP2-13167 from Novus Biologicals

Prices $99.00, $279.00
Sizes 25 µl, 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2
Western Blot: ERManI Antibody (3C2) [NBP2-13167] - Western blot analysis of ERManI expression in 1) NTERA-2 and 2) A-431 whole cell lysates.

ERManI Antibody (6B1) - H00011253-M01 from Novus Biologicals

Prices $349.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6B1
Western Blot: ERManI Antibody (6B1) [H00011253-M01] - ERManI expression in A-431 ( Cat # L015V1 ).

ERManI Antibody - NBP1-31448 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: ERManI Antibody [NBP1-31448] - Analysis of NBP1-31448 on Hela, with 7.5% SDS PAGE, diluted at 1:1000.

ERManI Antibody (3C2) [DyLight 550] - NBP2-13167R from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

ERManI Antibody (3C2) [HRP] - NBP2-13167H from Novus Biologicals

Prices $309.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

ERManI Antibody (3C2) [DyLight 488] - NBP2-13167G from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

ERManI Antibody (3C2) [DyLight 650] - NBP2-13167C from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

ERManI Antibody (3C2) [Biotin] - NBP2-13167B from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

ERManI Antibody (3C2) [FITC] - NBP2-13167F from Novus Biologicals

Prices $299.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

ERManI Antibody (3C2) [DyLight 405] - NBP2-13167V from Novus Biologicals

Prices $319.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3C2

ERManI Antibody (3C2) [Alexa Fluor (R) 700] - NBP2-13167AF700 from Novus Biologicals

Prices $319.00
Sizes 100 tests
Host Mouse
Clonality Monoclonal
Clone 3C2
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