MAN1B1

Gene Symbol MAN1B1
Entrez Gene 11253
Alt Symbol ERMAN1, MANA-ER, MRT15
Species Human
Gene Type protein-coding
Description mannosidase, alpha, class 1B, member 1
Other Description ER alpha 1,2-mannosidase|Man9GlcNAc2-specific processing alpha-mannosidase|endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase|endoplasmic reticulum mannosyl-oligosaccharide 1,2-alpha-mannosidase 1
Swissprots Q9Y5K7 Q9BRS9 Q5VSG3 Q9UKM7
Accessions EAW88345 EAW88346 EAW88347 Q9UKM7 AB209276 BAD92513 AF145732 AAD45504 AF148509 AAF03215 AI312031 AK074559 BAC11060 AK074699 BAG51987 AK094878 AK126926 AK127005 AK128033 AK128257 BAG54653 AK128341 BAG54664 AK130143 AK298480 BAG60691 AK299043 BAG61117 AK309808 AK315797 AL110221 CAB53680 AY358465 AAQ88830 BC002953 AAH02953 BC006079 AAH06079 BE731944 BM848429 BQ448144 CR749534 CAH18340 DA763005 DQ891861 ABM82787 DQ895050 ABM85976 XM_006716945 XP_006717008 NM_016219 NP_057303 NR_045720 NR_045721
Function Involved in glycoprotein quality control targeting of misfolded glycoproteins for degradation. It primarily trims a single alpha-1,2-linked mannose residue from Man(9)GlcNAc(2) to produce Man(8)GlcNAc(2), but at high enzyme concentrations, as found in the ER quality control compartment (ERQC), it further trims the carbohydrates to Man(5-6)GlcNAc(2). {ECO:0000269|PubMed:12090241, ECO:0000269|PubMed:18003979}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:10409699}; Single-pass type II membrane protein {ECO:0000269|PubMed:10409699}.
Tissue Specificity Widely expressed. {ECO:0000269|PubMed:10409699, ECO:0000269|PubMed:10521544}.
Top Pathways N-Glycan biosynthesis, Protein processing in endoplasmic reticulum

MAN1B1 CRISPR/Cas9 KO Plasmid (h) - sc-405117 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 HDR Plasmid (h) - sc-405117-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 Double Nickase Plasmid (h) - sc-405117-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 Double Nickase Plasmid (h2) - sc-405117-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 CRISPR Activation Plasmid (h) - sc-405117-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 CRISPR Activation Plasmid (h2) - sc-405117-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 Lentiviral Activation Particles (h) - sc-405117-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 Lentiviral Activation Particles (h2) - sc-405117-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 siRNA (h) - sc-92479 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAN1B1 shRNA Plasmid (h) - sc-92479-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MAN1B1 shRNA (h) Lentiviral Particles - sc-92479-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ERManI RNAi - H00011253-R01 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU028261 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12963 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05381 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05381

MAN1B1 siRNA (Human) - CRH7714 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MAN1B1 CRISPR/Cas9 KO Plasmid (h2) - sc-405117-KO-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MAN1B1 HDR Plasmid (h2) - sc-405117-HDR-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

shRNA set against Human MAN1B1 (NM_016219.4) - SHH337275 from Creative biogene

Category siRNA
Species Reactivities Human

Human MAN1B1 siRNA - orb268216 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

MAN1B1 shRNA Plasmid (Human) - CHH7714 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MAN1B1 miRNA 3'UTR clone - MiUTR3H-06729 from Creative biogene

Species Reactivities Human
Search more