C4B

Gene Symbol	C4B
Entrez Gene	721
Alt Symbol	C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
Species	Human
Gene Type	protein-coding
Description	complement component 4B (Chido blood group)
Other Description	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3|Chido form of C4|basic complement C4|complement C4-B|complement C4B1a
Swissprots	P78445 A7E2V2 Q6U2M5 Q6U2L1 Q5JNX2 Q9NPK5 Q6U2F3 Q6U2G0 P01028 Q13906 Q6U2I5 Q6U2L7 Q14835 Q6U2E9 Q96SA8 Q5JQM8 A6NHJ5 Q6P4R1 P0C0L4 Q96EG2 B0QZR6 Q96SA7 Q6U2L9 Q6U2F4 B2RUT6 Q4LE82 Q6U2F6 B0V2C8 Q6U2F8 A6H8M8 Q6VCV8 Q6U2F0 B7ZVZ6 Q6U2E5 A2BHY4 Q6U2G1 Q6U2E8 Q14033 Q9UIP5 P0C0L5 Q13160
Accessions	AAA99717 AAB67980 AAC98380 AAK49810 AAK49811 AAQ99144 AAR89087 AAR89088 AAR89089 AAR89090 AAR89092 AAR89094 AAR89095 AAR89096 AAR89097 AAR89098 AAR89099 AAR89100 AAR89101 AAR89102 AAR89103 AAR89104 AAR89105 AAR89106 AAR89111 AAR89113 AAR89128 AAR89129 AAR89131 AAR89133 AAR89135 AAR89137 AAR89138 AAR89151 AAR89152 AAR89153 AAR89154 AAR89163 CAB89302 P0C0L5 AK304564 BAG65356 BC172377 AAI72377 BM672834 BQ960796 CD624022 DA395398 DA918359 K02404 AAA59651 NM_001002029 NP_001002029
Function	Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
Subcellular Location	Secreted.
Tissue Specificity	Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response. {ECO:0000269|PubMed:11367523}.
Top Pathways	Complement and coagulation cascades, Systemic lupus erythematosus, Staphylococcus aureus infection, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human C4b ELISA Kit - abx150865 from Abbexa Category ELISA Kit Sensitivity 2.1 ng/ml Range 4.688 ng/ml - 300 ng/ml

Complement Component 4b, C4b, Human, ELISA Kit - E-EL-H0823 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 2.813 Range 4.688-300ng/mL

CH (Cholesterol), Human, ELISA Kit - E-EL-H0726 from ARP American Research Products Category ELISA Kit Prices $617.40 Sizes 96 t Sensitivity 0.094 _mol/mL Range 0.156-10_mol/mL

Complement C4-B, C4B, Human, ELISA Kit - E11254h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.78-50 ng/mL

Complement Component 4b (C4b), Human, ELISA Kit - SEB305Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 1.8ng/mL Range 4.7-300ng/mL

CH (Cholesterol), Mouse, ELISA Kit - E-EL-M1359 from ARP American Research Products Category ELISA Kit Prices $617.40 Sizes 96 t

CH (Cholesterol), Rat, ELISA Kit - E-EL-R0200 from ARP American Research Products Category ELISA Kit Prices $617.40 Sizes 96 t Sensitivity 0.094 mmol/L Range 0.156-10mmol/L

Complement Component 4b, C4b, Rabbit, ELISA Kit - E-EL-RB1450 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CH (Cholesterol), Rabbit, ELISA Kit - E-EL-RB1047 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

Complement Component 4b, C4b, Chicken, ELISA Kit - E-EL-Ch2108 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

CH (Cholesterol), Chicken, ELISA Kit - E-EL-Ch1203 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

Complement Component 4b, C4b, Porcine, ELISA Kit - E-EL-P0872 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CH (Cholesterol), Pig, ELISA Kit - E-EL-P0881 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

CH (Cholesterol), Guinea Pig, ELISA Kit - E-EL-GP0345 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

Complement Component 4b, C4b, Monkey, ELISA Kit - E-EL-MK1930 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

CH (Cholesterol), Monkey, ELISA Kit - E-EL-MK0208 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

Cholesterol, CH, General, ELISA Kit - E1701Ge from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t Range 0.156-10 nmol/mL

Human CH ELISA Kit - HC0752 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human C4B ELISA Kit - HC0371 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine C4B ELISA Kit - AC0371 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine CH ELISA Kit - AC0752 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

C4b, ELISA Kit - MBS2504720 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.813ng/mL Range 4.688-300ng/mL

C4b, ELISA Kit - MBS2502718 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.141ng/mL Range 0.234-15ng/mL

C4b, ELISA Kit - MBS2503781 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 2.813ng/mL Range 4.688--300ng/mL

C4b - MBS2506151 from MyBioSource Category ELISA Kit Prices $475.00, $575.00 Sizes 48 strip wells, 96 strip wells

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