C4B

Gene Symbol	C4B
Entrez Gene	721
Alt Symbol	C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
Species	Human
Gene Type	protein-coding
Description	complement component 4B (Chido blood group)
Other Description	C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3|Chido form of C4|basic complement C4|complement C4-B|complement C4B1a
Swissprots	P78445 A7E2V2 Q6U2M5 Q6U2L1 Q5JNX2 Q9NPK5 Q6U2F3 Q6U2G0 P01028 Q13906 Q6U2I5 Q6U2L7 Q14835 Q6U2E9 Q96SA8 Q5JQM8 A6NHJ5 Q6P4R1 P0C0L4 Q96EG2 B0QZR6 Q96SA7 Q6U2L9 Q6U2F4 B2RUT6 Q4LE82 Q6U2F6 B0V2C8 Q6U2F8 A6H8M8 Q6VCV8 Q6U2F0 B7ZVZ6 Q6U2E5 A2BHY4 Q6U2G1 Q6U2E8 Q14033 Q9UIP5 P0C0L5 Q13160
Accessions	AAA99717 AAB67980 AAC98380 AAK49810 AAK49811 AAQ99144 AAR89087 AAR89088 AAR89089 AAR89090 AAR89092 AAR89094 AAR89095 AAR89096 AAR89097 AAR89098 AAR89099 AAR89100 AAR89101 AAR89102 AAR89103 AAR89104 AAR89105 AAR89106 AAR89111 AAR89113 AAR89128 AAR89129 AAR89131 AAR89133 AAR89135 AAR89137 AAR89138 AAR89151 AAR89152 AAR89153 AAR89154 AAR89163 CAB89302 P0C0L5 AK304564 BAG65356 BC172377 AAI72377 BM672834 BQ960796 CD624022 DA395398 DA918359 K02404 AAA59651 NM_001002029 NP_001002029
Function	Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
Subcellular Location	Secreted.
Tissue Specificity	Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response. {ECO:0000269|PubMed:11367523}.
Top Pathways	Complement and coagulation cascades, Systemic lupus erythematosus, Staphylococcus aureus infection, Pertussis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human C4b peptide - ab74629 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

Human C4b protein fragment - ab112255 from Abcam Category Protein Prices $402.00 Sizes 10 µg Source Wheat germ Species Human

Human C4b protein fragment - ab114287 from Abcam Category Protein Prices $420.00 Sizes 10 µg Source Wheat germ Species Human

Recombinant Human Complement C4b Protein - H00000721-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Complement C4b Protein - H00000721-Q02 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Human C4B protein - orb246048 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

Human C4B protein - orb244655 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

C4B - H00000721-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

Complement C4B - H00000721-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Complement C4B - H00000721-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Complement C4B - H00000721-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Recombinant Human C4B - C4B-26130TH from Creative Biomart Category Protein Source Wheat germ

Recombinant Human C4B - C4B-27789TH from Creative Biomart Category Protein Source Wheat germ

Native Human C4B Protein - C4B-1846H from Creative Biomart Category Protein Source Human Plasma Species Human

Native Human C4b Binding Protein - C4B-99H from Creative Biomart Category Protein Source Normal human serum (shown by certified tests to be negative for HBsAg and for antibodies to HCV, HIV-1 and HIV-II). Species Human

Recombinant Complement Component 4b (C4b) - RPB305Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant Complement Component 4b (C4b) - RPB305Mu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Complement Component 4b (C4b) - RPB305Mu02 from Uscn Life Science Inc. Category Protein Source E.coli Species Mouse

Recombinant Complement Component 4b (C4b) - RPB305Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Complement C4-B(C4B) - CSB-YP313364HU CSB-BP313364HU CSB-MP313364HU from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Human

Recombinant Human Complement C4-B(C4B) - CSB-EP313364HU from Cusabio Category Protein Source Yeast Species Human

Native Human Complement Component C4c - CRC165A from Cell Science Prices $210.00 Sizes 200 µg Species Human

Native Human Complement Component C4c - CRC165B from Cell Science Prices $570.00 Sizes 1 mg Species Human

Native Human Complement Component C4c - CRC165C from Cell Science Prices $4,400.00 Sizes 10 mg Species Human

C4B Peptide, Human - M34GP02046H from Creative Peptides Category Peptide Source Synthetic. Species Human

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