C4B

Gene Symbol C4B
Entrez Gene 721
Alt Symbol C4B1, C4B12, C4B2, C4B3, C4B5, C4BD, C4B_2, C4F, CH, CO4, CPAMD3
Species Human
Gene Type protein-coding
Description complement component 4B (Chido blood group)
Other Description C3 and PZP-like alpha-2-macroglobulin domain-containing protein 3|Chido form of C4|basic complement C4|complement C4-B|complement C4B1a
Swissprots P78445 A7E2V2 Q6U2M5 Q6U2L1 Q5JNX2 Q9NPK5 Q6U2F3 Q6U2G0 P01028 Q13906 Q6U2I5 Q6U2L7 Q14835 Q6U2E9 Q96SA8 Q5JQM8 A6NHJ5 Q6P4R1 P0C0L4 Q96EG2 B0QZR6 Q96SA7 Q6U2L9 Q6U2F4 B2RUT6 Q4LE82 Q6U2F6 B0V2C8 Q6U2F8 A6H8M8 Q6VCV8 Q6U2F0 B7ZVZ6 Q6U2E5 A2BHY4 Q6U2G1 Q6U2E8 Q14033 Q9UIP5 P0C0L5 Q13160
Accessions AAA99717 AAB67980 AAC98380 AAK49810 AAK49811 AAQ99144 AAR89087 AAR89088 AAR89089 AAR89090 AAR89092 AAR89094 AAR89095 AAR89096 AAR89097 AAR89098 AAR89099 AAR89100 AAR89101 AAR89102 AAR89103 AAR89104 AAR89105 AAR89106 AAR89111 AAR89113 AAR89128 AAR89129 AAR89131 AAR89133 AAR89135 AAR89137 AAR89138 AAR89151 AAR89152 AAR89153 AAR89154 AAR89163 CAB89302 P0C0L5 AK304564 BAG65356 BC172377 AAI72377 BM672834 BQ960796 CD624022 DA395398 DA918359 K02404 AAA59651 NM_001002029 NP_001002029
Function Non-enzymatic component of the C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. C4A isotype is responsible for effective binding to form amide bonds with immune aggregates or protein antigens, while C4B isotype catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
Subcellular Location Secreted.
Tissue Specificity Complement component C4 is expressed at highest levels in the liver, at moderate levels in the adrenal cortex, adrenal medulla, thyroid gland,and the kidney, and at lowest levels in the heart, ovary, small intestine, thymus, pancreas and spleen. The extra-hepatic sites of expression may be important for the local protection and inflammatory response. {ECO:0000269|PubMed:11367523}.
Top Pathways Complement and coagulation cascades, Systemic lupus erythematosus, Staphylococcus aureus infection, Pertussis

C4b CRISPR/Cas9 KO Plasmid (h) - sc-416372 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C4b HDR Plasmid (h) - sc-416372-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C4b Double Nickase Plasmid (h) - sc-416372-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C4b Double Nickase Plasmid (h2) - sc-416372-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C4b CRISPR Activation Plasmid (h) - sc-416372-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C4b CRISPR Activation Plasmid (h2) - sc-416372-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

C4b Lentiviral Activation Particles (h) - sc-416372-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

C4b Lentiviral Activation Particles (h2) - sc-416372-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN4929 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND4929 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00157 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00157

C4B siRNA (Human) - CRH0500 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Complement C4b RNAi - H00000721-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

C4A - MBS8211145 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C4B - MBS8241347 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C4B_2 - MBS8222248 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human C4B_2 siRNA - orb279390 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

C4B shRNA Plasmid (Human) - CHH0500 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

C4B miRNA 3'UTR clone - MiUTR3H-00514 from Creative biogene

Species Reactivities Human
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