XIAP

Gene Symbol	XIAP
Entrez Gene	331
Alt Symbol	API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
Species	Human
Gene Type	protein-coding
Description	X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase XIAP|IAP-like protein|X-linked IAP|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3
Swissprots	D3DTF2 P98170 Q9NQ14
Accessions	AAW62257 CAW32364 CAW32374 EAX11858 EAX11859 EAX11860 EAX11861 P98170 AK130423 AK309704 AK313883 BAG36609 BC030771 BC032729 AAH32729 BQ423165 DA316362 DQ890857 ABM81783 DQ894012 ABM84938 H09548 U32974 AAC50518 XM_006724754 XP_006724817 XM_011531329 XP_011529631 NM_001167 NP_001158 NM_001204401 NP_001191330 NR_037916
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can
Subcellular Location	Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.
Tissue Specificity	Ubiquitous, except peripheral blood leukocytes.
Top Pathways	Apoptosis, Ubiquitin mediated proteolysis, Focal adhesion, Small cell lung cancer, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

XIAP (API3) Human ELISA Kit - ab155446 from Abcam Category ELISA Kit Prices $499.00 Sizes 1 x 96 tests Sensitivity < 0.25 ng/ml Range 2.5 ng/ml - 600 ng/ml

Human XIAP ELISA Kit - RAB0517 from Sigma-Aldrich Category ELISA Kit Prices $608.00 Sizes 1 kt

Mouse/Human/Rat XIAP ELISA Kit (Cell-Based ELISA) - LS-F2391 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 2.458-240 ng/ml

Human XIAP ELISA Kit (Sandwich ELISA) - LS-F215 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 2.458 ng/ml Range 2.458-240 ng/ml

Human XIAP ELISA Kit (Sandwich ELISA) - LS-F7096 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.103 ng/ml Range 2.458-240 ng/ml

Human Total XIAP DuoSet IC ELISA - DYC822-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 312.00 - 20,000 pg/mL

Human Total XIAP DuoSet IC, 5 Plate - DYC822-5 from R&D Systems Category ELISA Kit

Human XIAP Ubiquitin Ligase Kit - Diablo Substrate - K-250 from R&D Systems Prices $395.00 Sizes 1 kit

Human XIAP ELISA kit - 55R-IB09620 from Fitzgerald Category ELISA Kit Prices $805.00 Sizes 96 wells

Baculoviral IAP repeat-containing protein 4 (XIAP), Human, ELISA Kit - E01B0986 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

X-linked Inhibitor of Apoptosis (XIAP), Human, ELISA - IB09620 from ARP American Research Products Category ELISA Kit Prices $773.00 Sizes 96 t

X-Linked Inhibitor Of Apoptosis Protein (XIAP), Human, ELISA Kit - SEC606Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.103ng/mL Range 0.312-20ng/mL

X-Linked Inhibitor Of Apoptosis Protein, XIAP, Rat, ELISA Kit - E-EL-R1080 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

X-Linked Inhibitor Of Apoptosis Protein (XIAP), Human, CLIA Kit - SCC606Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.067ng/mL Range 0.156-10ng/mL

XIAP (Human) IP-WB Antibody Pair - H00000331-PW1 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human XIAP ELISA - ELH-XIAP from RayBiotech Category ELISA Kit Prices $560.00, $1,008.00, $2,241.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 250 pg/ml Range 0.25 ng/ml - 600 ng/ml

XIAP, ELISA Kit - MBS494354 from MyBioSource Category ELISA Kit Prices $690.00 Sizes 96 tests

XIAP Colorimetric Cell-Based ELISA Kit - CB5732 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human XIAP ELISA Kit - DEIA5868 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of XIAP is typically less than 0.25 ng/mL.

human XIAP ELISA Kit - DEIA6504 from Creative Diagnostics Category ELISA Kit Sensitivity 90.6 pg/mL

Epstein Barr Virus Induced Protein 3, ELISA Kit - MBS067842 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epstein Barr Virus Induced Protein 3, ELISA Kit - MBS092185 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epstein Barr Virus Induced Protein 3, ELISA Kit - MBS093219 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epstein Barr Virus Induced Protein 3, ELISA Kit - MBS103461 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Epstein Barr Virus Induced Protein 3, ELISA Kit - MBS074792 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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