XIAP

Gene Symbol	XIAP
Entrez Gene	331
Alt Symbol	API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
Species	Human
Gene Type	protein-coding
Description	X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase XIAP|IAP-like protein|X-linked IAP|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3
Swissprots	D3DTF2 P98170 Q9NQ14
Accessions	AAW62257 CAW32364 CAW32374 EAX11858 EAX11859 EAX11860 EAX11861 P98170 AK130423 AK309704 AK313883 BAG36609 BC030771 BC032729 AAH32729 BQ423165 DA316362 DQ890857 ABM81783 DQ894012 ABM84938 H09548 U32974 AAC50518 XM_006724754 XP_006724817 XM_011531329 XP_011529631 NM_001167 NP_001158 NM_001204401 NP_001191330 NR_037916
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can
Subcellular Location	Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.
Tissue Specificity	Ubiquitous, except peripheral blood leukocytes.
Top Pathways	Apoptosis, Ubiquitin mediated proteolysis, Focal adhesion, Small cell lung cancer, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human XIAP full length protein - ab95933 from Abcam Category Protein Prices $396.00 Sizes 20 µg Source Baculovirus Species Human

Active human XIAP peptide - ab41843 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Active human XIAP protein fragment - ab198451 from Abcam Category Protein Prices $911.00 Sizes 50 µg Source E. coli Species Human

Human XIAP full length protein - ab125537 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human XIAP protein fragment - ab157896 from Abcam Category Protein Source Wheat germ Species Human

XIAP peptide - ab38275 from Abcam Category Peptide

XIAP Antibody Blocking Peptide - LS-E30072 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

XIAP Antibody Blocking Peptide - LS-E8084 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human XIAP Protein - H00000331-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

XIAP Peptide - NBP1-77173PEP from Novus Biologicals Category Peptide Prices $149.00 Sizes 50 µg Species Human

XIAP Peptide - P1734 from Novus Biologicals Category Peptide Species Human

XIAP-BIRC4-Antibody-N-term-Blocking-peptide - BP6125a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human XIAP (BIR3), CF - 895-XB-050 from R&D Systems Category Protein Source E. coli-derived, Asn252-Thr356, with an N-terminal Met and 6-His tag

Recombinant Human XIAP (Full Length), CF - 822-XF-050 from R&D Systems Category Protein Source E. coli-derived

Recombinant Human XIAP Western Blot Standard Protein - WBC002 from R&D Systems Category Protein Prices $109.00 Sizes 100 µl Species Human

Recombinant Human XIAP (BIR2), CF - 786-XB-050 from R&D Systems Category Protein Source E. coli-derived, Ala124-Ala242, with an N-terminal Met and 6-His tag

Human XIAP protein - orb246242 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

XIAP (His Tag) protein - orb171611 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source E. coli Species Human

XIAP Blocking Peptide - 33R-10659 from Fitzgerald Category Peptide Prices $115.00 Sizes 50 µg

IAP3 / BIRC4 - H00000331-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

IAP3 / BIRC4 - H00000331-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

IAP3 / BIRC4 control peptide - AP00062CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

IAP3 / BIRC4 Control Peptide - AP30993CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

Recombinant Human X-linked IAP (BIRC4) - 230-00683-10 from RayBiotech Category Protein Prices $86.00 Sizes 10 µg Source Escherichia coli (E.coli) Species Human

Recombinant Human X-linked IAP (BIRC4) - 230-00683-50 from RayBiotech Category Protein Prices $172.00 Sizes 50 µg Source Escherichia coli (E.coli) Species Human

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