XIAP

Gene Symbol	XIAP
Entrez Gene	331
Alt Symbol	API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3
Species	Human
Gene Type	protein-coding
Description	X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase XIAP|IAP-like protein|X-linked IAP|baculoviral IAP repeat-containing protein 4|inhibitor of apoptosis protein 3
Swissprots	D3DTF2 P98170 Q9NQ14
Accessions	AAW62257 CAW32364 CAW32374 EAX11858 EAX11859 EAX11860 EAX11861 P98170 AK130423 AK309704 AK313883 BAG36609 BC030771 BC032729 AAH32729 BQ423165 DA316362 DQ890857 ABM81783 DQ894012 ABM84938 H09548 U32974 AAC50518 XM_006724754 XP_006724817 XM_011531329 XP_011529631 NM_001167 NP_001158 NM_001204401 NP_001191330 NR_037916
Function	Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and the target proteins for its E3 ubiquitin-protein ligase activity include: RIPK1, CASP3, CASP7, CASP8, CASP9, MAP3K2/MEKK2, DIABLO/SMAC, AIFM1, CCS and BIRC5/survivin. Ubiquitinion of CCS leads to enhancement of its chaperone activity toward its physiologic target, SOD1, rather than proteasomal degradation. Ubiquitinion of MAP3K2/MEKK2 and AIFM1 does not lead to proteasomal degradation. Plays a role in copper homeostasis by ubiquitinationg COMMD1 and promoting its proteasomal degradation. Can
Subcellular Location	Cytoplasm. Nucleus. Note=TLE3 promotes its nuclear localization.
Tissue Specificity	Ubiquitous, except peripheral blood leukocytes.
Top Pathways	Apoptosis, Ubiquitin mediated proteolysis, Focal adhesion, Small cell lung cancer, Toxoplasmosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® XIAP siRNA I - 6446 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (50-100 transfections) Species Reactivities Human

SignalSilence ® XIAP siRNA II - 6550 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

XIAP CRISPR/Cas9 KO Plasmid (h) - sc-416497 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

XIAP HDR Plasmid (h) - sc-416497-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

XIAP Double Nickase Plasmid (h) - sc-416497-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

XIAP Double Nickase Plasmid (h2) - sc-416497-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

XIAP CRISPR Activation Plasmid (h) - sc-416497-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

XIAP CRISPR Activation Plasmid (h2) - sc-416497-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

XIAP Lentiviral Activation Particles (h) - sc-416497-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

XIAP Lentiviral Activation Particles (h2) - sc-416497-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

XIAP siRNA (h) - sc-37508 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

XIAP shRNA Plasmid (h) - sc-37508-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

XIAP shRNA (h) Lentiviral Particles - sc-37508-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

XIAP RNAi - H00000331-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU104221 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU111091 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1588 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1588 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

XIAP siRNA (Human) - CRH0232 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

XIAP - MBS8218021 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Human XIAP siRNA - orb260734 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

XIAP shRNA Plasmid (Human) - CHH0232 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

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