FLNC

Gene Symbol	FLNC
Entrez Gene	2318
Alt Symbol	ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4
Species	Human
Gene Type	protein-coding
Description	filamin C, gamma
Other Description	ABP-280-like protein\|ABP-L, gamma filamin\|actin binding protein 280\|filamin-2\|filamin-C
Swissprots	Q9NYE5 Q07985 Q9UMR8 B2ZZ88 Q9Y503 Q14315 Q9NS12 O95303
Accessions	AAF67190 AAF68195 ACF49257 CAB51535 EAW83689 EAW83690 EAW83691 Q14315 AB208865 BAD92102 AB371585 BAG48314 AF089841 AAD12245 AF146692 AAF80245 AJ012737 CAB46442 AK001048 BAG50853 AK126540 F30928 X70083 CAA49688 X70084 CAA49689 NM_001127487 NP_001120959 NM_001458 NP_001449
Function	Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
Subcellular Location	Cytoplasm {ECO:0000269\|PubMed:11038172}. Membrane {ECO:0000269\|PubMed:11038172}; Peripheral membrane protein {ECO:0000269\|PubMed:11038172}. Cytoplasm, cytoskeleton {ECO:0000269\|PubMed:11038172}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269\|PubMed:11038172}. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.
Tissue Specificity	Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney. {ECO:0000269\|PubMed:11038172, ECO:0000269\|PubMed:7689010, ECO:0000269\|PubMed:9791010}.
Top Pathways	Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer

Filamin C Antibody - 12037 from Cell Signaling Technology

Prices	$239.00
Sizes	100 µl (10 western blots)
Host	Rabbit
Clonality	Polyclonal

Western blot analysis of extracts from human skeletal muscle and RD cells using Filamin C Antibody.

Filamin 2 (C-20) - sc-48495 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Filamin 2 (C-20): sc-48495. Western blot analysis of Filamin 2 expression in A-10 whole cell lysate (A) and rat skeletal muscle tissue extract (B).

Filamin 2 (K-18) - sc-48496 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Filamin 2 (K-18): sc-48496. Western blot analysis of Filamin 2 expression in Sol8 (A) and A-10 (B) whole cell lysates and rat skeletal muscle tissue extract (C).

Anti-FLNC (phospho S2113) antibody - ab20485 from Abcam

Prices	$370.00
Sizes	50 µl
Host	Rabbit
Clonality	Polyclonal

Anti-FLNC antibody [EPR14498(B)] - ab180941 from Abcam

Prices	$347.00
Sizes	100 µl
Host	Rabbit
Clonality	Monoclonal
Clone	EPR14498(B)

All lanes : Anti-FLNC antibody [EPR14498(B)] (ab180941) at 1/50000 dilutionLane 1 : Human skeletal muscle lysateLane 2 : Human fetal heart lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-ABP-280 / FLNC Antibody (aa2519-2725, Biotin) - LS-C298042 from LifeSpan Bioscience

Prices	$425.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ABP-280 / FLNC Antibody (aa2519-2725, FITC) - LS-C301818 from LifeSpan Bioscience

Prices	$455.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Anti-ABP-280 / FLNC Antibody (aa586-635) - LS-C151717 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

ABP-280 / FLNC antibody Western Blot of HepG2.

Anti-ABP-280 / FLNC Antibody (aa2519-2725) - LS-C293946 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Western blot of recombinant ABP-280 / FLNC.

Anti-ABP-280 / FLNC Antibody (aa17-259) - LS-C293948 from LifeSpan Bioscience

Prices	$405.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

FLNC Antibody - NBP1-89300 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunocytochemistry/Immunofluorescence: FLNC Antibody [NBP1-89300] - Immunofluorescent staining of human cell line U-2 OS shows localization to plasma membrane & cytosol.

Filamin Antibody (FLMN01 (PM6/317)) - NB600-1218 from Novus Biologicals

Prices	$299.00
Sizes	500 µl
Host	Mouse
Clonality	Monoclonal
Clone	FLMN01 (PM6/317)

Western Blot: Filamin Antibody (FLMN01 (PM6/317)) [NB600-1218] - Analysis of 7.5ug of HeLa cell lysate per well.

FLNC Antibody - H00002318-A01 from Novus Biologicals

Prices	$269.00
Sizes	50 µl
Host	Mouse
Clonality	Polyclonal

Western Blot: FLNC Antibody [H00002318-A01] - FLNC polyclonal antibody (A01), Lot # FAK0070504QCS1 Western Blot analysis of FLNC expression in NIH/3T3 ( Cat # L018V1 ).

Filamin 2 Polyclonal Antibody - bs-13182R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Paraformaldehyde-fixed, paraffin embedded Mouse heart; Antigen retrieval by boiling in sodium citrate buffer (pH6.0) for 15min; Block endogenous peroxidase by 3% hydrogen peroxide for 20 minutes; Blocking buffer (normal goat serum) at 37°C for 30min; Antibody incubation with Filamin 2 Polyclonal Antibody, Unconjugated (bs-13182R) at 1:400 overnight at 4°C, followed by a conjugated secondary and DAB staining.

FLNC (Ser2233) Polyclonal Antibody - bs-13183R from Bioss

Prices	$289.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13182R-A350 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13182R-A488 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13182R-A555 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13182R-A647 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, Cy3 Conjugated - bs-13182R-Cy3 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, Cy5 Conjugated - bs-13182R-Cy5 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, Cy5.5 Conjugated - bs-13182R-Cy5.5 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, Cy7 Conjugated - bs-13182R-Cy7 from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, FITC Conjugated - bs-13182R-FITC from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Filamin 2 Polyclonal Antibody, Biotin Conjugated - bs-13182R-Biotin from Bioss

Prices	$349.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Search more