| Gene Symbol |
FLNC
|
| Entrez Gene |
2318
|
| Alt Symbol |
ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
filamin C, gamma
|
| Other Description |
ABP-280-like protein|ABP-L, gamma filamin|actin binding protein 280|filamin-2|filamin-C
|
| Swissprots |
Q9NYE5 Q07985 Q9UMR8 B2ZZ88 Q9Y503 Q14315 Q9NS12 O95303
|
| Accessions |
AAF67190 AAF68195 ACF49257 CAB51535 EAW83689 EAW83690 EAW83691 Q14315 AB208865 BAD92102 AB371585 BAG48314 AF089841 AAD12245 AF146692 AAF80245 AJ012737 CAB46442 AK001048 BAG50853 AK126540 F30928 X70083 CAA49688 X70084 CAA49689 NM_001127487 NP_001120959 NM_001458 NP_001449
|
| Function |
Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:11038172}. Membrane {ECO:0000269|PubMed:11038172}; Peripheral membrane protein {ECO:0000269|PubMed:11038172}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11038172}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11038172}. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert.
|
| Tissue Specificity |
Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney. {ECO:0000269|PubMed:11038172, ECO:0000269|PubMed:7689010, ECO:0000269|PubMed:9791010}.
|
| Top Pathways |
Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer
|