FLNC
| Gene Symbol | FLNC |
|---|---|
| Entrez Gene | 2318 |
| Alt Symbol | ABP-280, ABP280A, ABPA, ABPL, FLN2, MFM5, MPD4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | filamin C, gamma |
| Other Description | ABP-280-like protein|ABP-L, gamma filamin|actin binding protein 280|filamin-2|filamin-C |
| Swissprots | Q9NYE5 Q07985 Q9UMR8 B2ZZ88 Q9Y503 Q14315 Q9NS12 O95303 |
| Accessions | AAF67190 AAF68195 ACF49257 CAB51535 EAW83689 EAW83690 EAW83691 Q14315 AB208865 BAD92102 AB371585 BAG48314 AF089841 AAD12245 AF146692 AAF80245 AJ012737 CAB46442 AK001048 BAG50853 AK126540 F30928 X70083 CAA49688 X70084 CAA49689 NM_001127487 NP_001120959 NM_001458 NP_001449 |
| Function | Muscle-specific filamin, which plays a central role in muscle cells, probably by functioning as a large actin-cross- linking protein. May be involved in reorganizing the actin cytoskeleton in response to signaling events, and may also display structural functions at the Z lines in muscle cells. Critical for normal myogenesis and for maintaining the structural integrity of the muscle fibers. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:11038172}. Membrane {ECO:0000269|PubMed:11038172}; Peripheral membrane protein {ECO:0000269|PubMed:11038172}. Cytoplasm, cytoskeleton {ECO:0000269|PubMed:11038172}. Cytoplasm, myofibril, sarcomere, Z line {ECO:0000269|PubMed:11038172}. Note=A small amount localizes at membranes. In striated muscle cells, it predominantly localizes in myofibrillar Z lines, while a minor fraction localizes with subsarcolemme. Targeting to developing and mature Z lines is mediated by the intradomain insert. |
| Tissue Specificity | Highly expressed in striated muscles. Weakly expressed in thyroid, fetal brain, fetal lung, retina, spinal cord and bone marrow. Not expressed in testis, pancreas, adrenal gland, placenta, liver and kidney. {ECO:0000269|PubMed:11038172, ECO:0000269|PubMed:7689010, ECO:0000269|PubMed:9791010}. |
| Top Pathways | Focal adhesion, MAPK signaling pathway, Salmonella infection, Proteoglycans in cancer |
Filamin 2 CRISPR/Cas9 KO Plasmid (h) - sc-402358 from Santa Cruz Biotechnology
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Filamin 2 HDR Plasmid (h) - sc-402358-HDR from Santa Cruz Biotechnology
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Filamin 2 Double Nickase Plasmid (h) - sc-402358-NIC from Santa Cruz Biotechnology
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Filamin 2 Double Nickase Plasmid (h2) - sc-402358-NIC-2 from Santa Cruz Biotechnology
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Filamin 2 CRISPR Activation Plasmid (h) - sc-402358-ACT from Santa Cruz Biotechnology
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Filamin 2 CRISPR Activation Plasmid (h2) - sc-402358-ACT-2 from Santa Cruz Biotechnology
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Filamin 2 Lentiviral Activation Particles (h) - sc-402358-LAC from Santa Cruz Biotechnology
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Filamin 2 Lentiviral Activation Particles (h2) - sc-402358-LAC-2 from Santa Cruz Biotechnology
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Filamin 2 siRNA (h) - sc-60639 from Santa Cruz Biotechnology
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Filamin 2 shRNA Plasmid (h) - sc-60639-SH from Santa Cruz Biotechnology
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Filamin 2 shRNA (h) Lentiviral Particles - sc-60639-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU134521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8824 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8824 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07153 from Sigma-Aldrich
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FLNC siRNA (Human) - CRH1623 from Cohesion Biosciences
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FLNC RNAi - H00002318-R01 from Novus Biologicals
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FLNC - MBS8238158 from MyBioSource
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Filamin 2 CRISPR/Cas9 KO Plasmid (h2) - sc-402358-KO-2 from Santa Cruz Biotechnology
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Filamin 2 HDR Plasmid (h2) - sc-402358-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human FLNC (NM_001458.4) - SHH295685 from Creative biogene
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Human FLNC siRNA - orb262125 from Biorbyt
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FLNC shRNA Plasmid (Human) - CHH1623 from Cohesion Biosciences
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FLNC miRNA 3'UTR clone - MiUTR3H-00018 from Creative biogene
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FLNC miRNA 3'UTR clone - MiUTR3H-00019 from Creative biogene
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