MAPKAP1
| Gene Symbol | MAPKAP1 |
|---|---|
| Entrez Gene | 79109 |
| Alt Symbol | JC310, MIP1, SIN1, SIN1b, SIN1g |
| Species | Human |
| Gene Type | protein-coding |
| Description | mitogen-activated protein kinase associated protein 1 |
| Other Description | MEKK2-interacting protein 1|SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mSIN1|mitogen-activated protein kinase 2-associated protein 1|ras inhibitor MGC2745|stress-activated map kinase interacting protein 1|stress-activated map kinase-interacting protein 1|stress-activated protein kinase-interacting 1|target of rapamycin complex 2 subunit MAPKAP1 |
| Swissprots | Q699U4 Q00426 Q6GVJ2 Q699U1 Q9BPZ7 Q6GVJ0 Q5JSV6 Q699U2 B7Z309 A8K1Z5 Q5JSV5 Q658R0 Q699U3 B1AMA4 Q5JSV9 Q6GVJ1 |
| Accessions | EAW87630 EAW87631 EAW87632 EAW87633 Q9BPZ7 AK290060 BAF82749 AK295364 BAH12045 AK298841 BAH12881 AK309507 AK310361 AK316149 BAH14520 AL833042 CAH56311 AY425957 AAR07950 AY524429 AAS90839 AY524430 AAS90840 AY524431 AAS90841 AY524432 AAS90842 AY633624 AAT46478 AY633625 AAT46479 AY633626 AAT46480 BC002326 AAH02326 BC003044 AAH03044 BC035236 BX438260 DQ892728 ABM83654 EU176718 ABW03519 M37191 AAA36551 XM_011519005 XP_011517307 XM_011519006 XP_011517308 XM_011519007 XP_011517309 XM_011519008 XP_011517310 XM_011519009 XP_011517311 XM_011519010 XP_011517312 NM_001006617 NP_001006618 NM_001006618 NP_001006619 NM_001006619 NP_001006620 NM_001006620 NP_001006621 NM_001006621 NP_001006622 NM_024117 NP_077022 |
| Function | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory |
| Subcellular Location | Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus. |
| Tissue Specificity | Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:15988011}. |
Rabbit anti-Sin1 Antibody, Affinity Purified - PLA0157 from Sigma-Aldrich
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), Human, ELISA Kit - E01T0631 from ARP American Research Products
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Macrophage Inflammatory Protein 1 Beta (MIP1b), ELISA Kit - MBS9308952 from MyBioSource
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Macrophage Inflammatory Protein 1 Beta (MIP1b), ELISA Kit - MBS9308193 from MyBioSource
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Macrophage Inflammatory Protein 1 Beta (MIP1b), ELISA Kit - MBS9308800 from MyBioSource
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Macrophage Inflammatory Protein 1 Beta (MIP1b), ELISA Kit - MBS9309136 from MyBioSource
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Macrophage Inflammatory Protein 1 Beta (MIP1b), ELISA Kit - MBS9307359 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1, ELISA Kit - MBS281070 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7246855 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7249927 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7203083 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7220799 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7251288 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7211879 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7242619 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7237001 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7208841 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7213768 from MyBioSource
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Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1), ELISA Kit - MBS7207918 from MyBioSource
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Human MAPKAP1 ELISA Kit - E037478 from Biobool
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Human Target of rapamycin complex 2 subunit MAPKAP1 (MAPKAP1) ELISA Kit - AE34278HU from ARP American Research Products
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