MAPKAP1

Gene Symbol	MAPKAP1
Entrez Gene	79109
Alt Symbol	JC310, MIP1, SIN1, SIN1b, SIN1g
Species	Human
Gene Type	protein-coding
Description	mitogen-activated protein kinase associated protein 1
Other Description	MEKK2-interacting protein 1|SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mSIN1|mitogen-activated protein kinase 2-associated protein 1|ras inhibitor MGC2745|stress-activated map kinase interacting protein 1|stress-activated map kinase-interacting protein 1|stress-activated protein kinase-interacting 1|target of rapamycin complex 2 subunit MAPKAP1
Swissprots	Q699U4 Q00426 Q6GVJ2 Q699U1 Q9BPZ7 Q6GVJ0 Q5JSV6 Q699U2 B7Z309 A8K1Z5 Q5JSV5 Q658R0 Q699U3 B1AMA4 Q5JSV9 Q6GVJ1
Accessions	EAW87630 EAW87631 EAW87632 EAW87633 Q9BPZ7 AK290060 BAF82749 AK295364 BAH12045 AK298841 BAH12881 AK309507 AK310361 AK316149 BAH14520 AL833042 CAH56311 AY425957 AAR07950 AY524429 AAS90839 AY524430 AAS90840 AY524431 AAS90841 AY524432 AAS90842 AY633624 AAT46478 AY633625 AAT46479 AY633626 AAT46480 BC002326 AAH02326 BC003044 AAH03044 BC035236 BX438260 DQ892728 ABM83654 EU176718 ABW03519 M37191 AAA36551 XM_011519005 XP_011517307 XM_011519006 XP_011517308 XM_011519007 XP_011517309 XM_011519008 XP_011517310 XM_011519009 XP_011517311 XM_011519010 XP_011517312 NM_001006617 NP_001006618 NM_001006618 NP_001006619 NM_001006619 NP_001006620 NM_001006620 NP_001006621 NM_001006621 NP_001006622 NM_024117 NP_077022
Function	Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory
Subcellular Location	Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Tissue Specificity	Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:15988011}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

MAPKAP-1 CRISPR/Cas9 KO Plasmid (h) - sc-404288 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MAPKAP-1 HDR Plasmid (h) - sc-404288-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAPKAP-1 Double Nickase Plasmid (h) - sc-404288-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAPKAP-1 Double Nickase Plasmid (h2) - sc-404288-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAPKAP-1 CRISPR Activation Plasmid (h) - sc-404288-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MAPKAP-1 CRISPR Activation Plasmid (h2) - sc-404288-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

MAPKAP-1 Lentiviral Activation Particles (h) - sc-404288-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAPKAP-1 Lentiviral Activation Particles (h2) - sc-404288-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

MAPKAP-1 siRNA (h) - sc-60984 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MAPKAP-1 shRNA Plasmid (h) - sc-60984-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

MAPKAP-1 shRNA (h) Lentiviral Particles - sc-60984-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Sin1/MAPKAP1 RNAi - H00079109-R10 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Sin1/MAPKAP1 RNAi - H00079109-R09 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Sin1/MAPKAP1 RNAi - H00079109-R07 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Sin1/MAPKAP1 RNAi - H00079109-R11 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

Sin1/MAPKAP1 RNAi - H00079109-R08 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN13020 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND13020 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09513 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09513

MAPKAP1 siRNA (Human) - CRJ2316 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Sin1/MAPKAP1 RNAi - H00079109-R12 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

shRNA set against Human MAPKAP1 (NM_024117.3) - SHH338135 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MAPKAP1(NM_001006617.1) - SHH176303 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MAPKAP1(NM_001006619.1) - SHH176321 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human MAPKAP1(NM_001006620.1) - SHH176335 from Creative biogene Category siRNA Species Reactivities Human

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