MAPKAP1

Gene Symbol MAPKAP1
Entrez Gene 79109
Alt Symbol JC310, MIP1, SIN1, SIN1b, SIN1g
Species Human
Gene Type protein-coding
Description mitogen-activated protein kinase associated protein 1
Other Description MEKK2-interacting protein 1|SAPK-interacting protein 1|TORC2 subunit MAPKAP1|mSIN1|mitogen-activated protein kinase 2-associated protein 1|ras inhibitor MGC2745|stress-activated map kinase interacting protein 1|stress-activated map kinase-interacting protein 1|stress-activated protein kinase-interacting 1|target of rapamycin complex 2 subunit MAPKAP1
Swissprots Q699U4 Q00426 Q6GVJ2 Q699U1 Q9BPZ7 Q6GVJ0 Q5JSV6 Q699U2 B7Z309 A8K1Z5 Q5JSV5 Q658R0 Q699U3 B1AMA4 Q5JSV9 Q6GVJ1
Accessions EAW87630 EAW87631 EAW87632 EAW87633 Q9BPZ7 AK290060 BAF82749 AK295364 BAH12045 AK298841 BAH12881 AK309507 AK310361 AK316149 BAH14520 AL833042 CAH56311 AY425957 AAR07950 AY524429 AAS90839 AY524430 AAS90840 AY524431 AAS90841 AY524432 AAS90842 AY633624 AAT46478 AY633625 AAT46479 AY633626 AAT46480 BC002326 AAH02326 BC003044 AAH03044 BC035236 BX438260 DQ892728 ABM83654 EU176718 ABW03519 M37191 AAA36551 XM_011519005 XP_011517307 XM_011519006 XP_011517308 XM_011519007 XP_011517309 XM_011519008 XP_011517310 XM_011519009 XP_011517311 XM_011519010 XP_011517312 NM_001006617 NP_001006618 NM_001006618 NP_001006619 NM_001006619 NP_001006620 NM_001006620 NP_001006621 NM_001006621 NP_001006622 NM_024117 NP_077022
Function Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient- insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphory
Subcellular Location Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle. Nucleus.
Tissue Specificity Ubiquitously expressed, with highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:15988011}.

Human-MAPKAP1-cDNA-Clone - DC00897 from Abgent, a WuXi AppTec company

Prices $445.50
Sizes 10 µg
Species Human
Accession NM_001006617

MAPKAP1 - MBS1269221 from MyBioSource

Species Human
Accession BC002326

Human MAPKAP1 cDNA clone(NM_024117.3) - CDFG004274 from Creative Biomart

Species Human
Accession NM_024117.3

Human MAPKAP1 cDNA clone(NM_001006618.1) - CDFH011054 from Creative Biomart

Species Human
Accession NM_001006618.1

Human MAPKAP1 cDNA clone(NM_001006620.1) - CDFH011055 from Creative Biomart

Species Human
Accession NM_001006620.1

Human MAPKAP1 cDNA clone(NM_001006617.1) - CDFH011056 from Creative Biomart

Species Human
Accession NM_001006617.1

Human MAPKAP1 cDNA clone(NM_001006619.1) - CDFH011057 from Creative Biomart

Species Human
Accession NM_001006619.1

Human MAPKAP1 cDNA clone(NM_001006621.1) - CDFH011058 from Creative Biomart

Species Human
Accession NM_001006621.1

Human MAPKAP1 ORF Clone(NM_024117.3) - CDCR308820 from Creative Biomart

Species Human
Accession NM_024117.3

Human MAPKAP1 ORF Clone(NM_024117.3) - CDCR308821 from Creative Biomart

Species Human
Accession NM_024117.3

Human MAPKAP1 ORF Clone(NM_001006617.1) - CDCR339993 from Creative Biomart

Species Human
Accession NM_001006617.1

Human MAPKAP1 ORF Clone(NM_001006617.1) - CDCR339994 from Creative Biomart

Species Human
Accession NM_001006617.1

Human MAPKAP1 ORF Clone(NM_001006617.1) - CDCR339995 from Creative Biomart

Species Human
Accession NM_001006617.1

Human MAPKAP1 ORF Clone(NM_001006618.1) - CDCR339996 from Creative Biomart

Species Human
Accession NM_001006618.1

Human MAPKAP1 ORF Clone(NM_001006618.1) - CDCR339997 from Creative Biomart

Species Human
Accession NM_001006618.1

Human MAPKAP1 ORF Clone(NM_001006619.1) - CDCR339998 from Creative Biomart

Species Human
Accession NM_001006619.1

Human MAPKAP1 ORF Clone(NM_001006619.1) - CDCR339999 from Creative Biomart

Species Human
Accession NM_001006619.1

Human MAPKAP1 ORF Clone(NM_001006620.1) - CDCR340000 from Creative Biomart

Species Human
Accession NM_001006620.1

Human MAPKAP1 ORF Clone(NM_001006620.1) - CDCR340001 from Creative Biomart

Species Human
Accession NM_001006620.1

Human MAPKAP1 ORF Clone(NM_001006621.1) - CDCR340002 from Creative Biomart

Species Human
Accession NM_001006621.1

Human MAPKAP1 ORF Clone(NM_001006621.1) - CDCR340003 from Creative Biomart

Species Human
Accession NM_001006621.1
Search more