Gene Symbol | Lrpprc |
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Entrez Gene | 72416 |
Alt Symbol | 3110001K13Rik, C76645, Gp130, Lrp130, Lsfc |
Species | Mouse |
Gene Type | protein-coding |
Description | leucine-rich PPR-motif containing |
Other Description | 130 kDa leucine-rich protein|leucine rich protein LRP130|leucine-rich PPR motif-containing protein, mitochondrial |
Swissprots | Q9CRX4 Q8K4V0 Q6PB66 |
Accessions | EDL38586 Q6PB66 AK013955 BAB29082 AK039751 AK138527 AK149503 BC004681 AAH04681 BC059862 AAH59862 BC060199 S81177 XM_011246643 XP_011244945 NM_028233 NP_082509 |
Function | May play a role in RNA metabolism in both nuclei and mitochondria. In the nucleus binds to HNRPA1-associated poly(A) mRNAs and is part of nmRNP complexes at late stages of mRNA maturation which are possibly associated with nuclear mRNA export. May bind mature mRNA in the nucleus outer membrane. In mitochondria binds to poly(A) mRNA. Plays a role in translation or stability of mitochondrially encoded cytochrome c oxidase (COX) subunits. May be involved in transcription regulation. Cooperates with PPARGC1A to regulate certain mitochondrially encoded genes and gluconeogenic genes and may regulate docking of PPARGC1A to transcription factors. Seems to be involved in the transcription regulation of the multidrug-related genes MDR1 and MVP. Part of a nuclear factor that binds to the invMED1 element of MDR1 and MVP gene promoters (By similarity). Binds single-stranded DNA. {ECO:0000250}. |
Subcellular Location | Mitochondrion {ECO:0000250}. Nucleus {ECO:0000269|PubMed:12071956}. Nucleus, nucleoplasm {ECO:0000250}. Nucleus inner membrane {ECO:0000250}. Nucleus outer membrane {ECO:0000250}. |
Tissue Specificity | Strongly expressed in heart, liver and kidney. Weakly expressed in brain, skeletal muscle and testes. {ECO:0000269|PubMed:12071956}. |
LRP130 CRISPR/Cas9 KO Plasmid (m) - sc-428337 from Santa Cruz Biotechnology
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LRP130 HDR Plasmid (m) - sc-428337-HDR from Santa Cruz Biotechnology
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LRP130 Double Nickase Plasmid (m) - sc-428337-NIC from Santa Cruz Biotechnology
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LRP130 Double Nickase Plasmid (m2) - sc-428337-NIC-2 from Santa Cruz Biotechnology
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LRP130 CRISPR Activation Plasmid (m) - sc-428337-ACT from Santa Cruz Biotechnology
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LRP130 CRISPR Activation Plasmid (m2) - sc-428337-ACT-2 from Santa Cruz Biotechnology
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LRP130 Lentiviral Activation Particles (m) - sc-428337-LAC from Santa Cruz Biotechnology
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LRP130 Lentiviral Activation Particles (m2) - sc-428337-LAC-2 from Santa Cruz Biotechnology
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LRP130 siRNA (m) - sc-44735 from Santa Cruz Biotechnology
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LRP130 shRNA Plasmid (m) - sc-44735-SH from Santa Cruz Biotechnology
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LRP130 shRNA (m) Lentiviral Particles - sc-44735-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU043701 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN34956 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND34956 from Sigma-Aldrich
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LRPPRC siRNA (Mouse) - CRM8788 from Cohesion Biosciences
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shRNA set against Mouse LRPPRC (NM_028233.2) - SHH334111 from Creative biogene
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shRNA set against Mouse Lrpprc(NM_028233.2) - SHH161579 from Creative biogene
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Mouse LRPPRC siRNA - orb288264 from Biorbyt
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LRPPRC shRNA Plasmid (Mouse) - CHM8788 from Cohesion Biosciences
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