| Gene Symbol |
GAPDH
|
| Entrez Gene |
100009074
|
| Alt Symbol |
-
|
| Species |
Rabbit
|
| Gene Type |
protein-coding
|
| Description |
glyceraldehyde-3-phosphate dehydrogenase
|
| Other Description |
peptidyl-cysteine S-nitrosylase GAPDH
|
| Swissprots |
P46406 Q4AC92
|
| Accessions |
P46406 AB128158 BAD04921 AB231852 BAE19661 DQ403051 ABD77184 L23961 AAA85218 V00884 CAA24253 NM_001082253 NP_001075722
|
| Function |
Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3- phosphate (G3P) into 3-phospho-D-glyceroyl phosphate. Modulates the organization and assembly of the cytoskeleton. Facilitates the CHP1-dependent microtubule and membrane associations through its ability to stimulate the binding of CHP1 to microtubules. Also participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S- nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC. Component of the GAIT (gamma interferon-activated inhibitor of translation) complex which mediates interferon-gamma-induced transcript-selective translation inhibition in infl
|
| Subcellular Location |
Cytoplasm, cytosol {ECO:0000250}. Nucleus {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=Translocates to the nucleus following S-nitrosylation and interaction with SIAH1, which contains a nuclear localization signal. {ECO:0000250}.
|
| Top Pathways |
Glycolysis / Gluconeogenesis, Alzheimer's disease, Biosynthesis of amino acids, Carbon metabolism
|