| Gene Symbol | Pdgfrb |
|---|---|
| Entrez Gene | 24629 |
| Alt Symbol | PDGFR-1 |
| Species | Rat |
| Gene Type | protein-coding |
| Description | platelet derived growth factor receptor, beta polypeptide |
| Other Description | CD140 antigen-like family member B|PDGF-R-beta|PDGFR-beta|Platelet-derived growth factor receptor, beta|beta platelet-derived growth factor receptor|beta-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 1|platelet-derived growth factor receptor beta|platelet-derived growth factor receptor beta variant 1 |
| Swissprots | Q925F7 Q05030 Q8R406 |
| Accessions | EDM14586 Q05030 AF359356 AAK43716 AY090783 AAM09098 DQ979389 ABJ53143 Z14119 CAA78489 XM_006254789 XP_006254851 XM_008772084 XP_008770306 NM_031525 NP_113713 |
| Function | Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGF |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Lysosome lumen {ECO:0000250}. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. {ECO:0000250}. |
| Top Pathways | Rap1 signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction |