Pdgfrb

Gene Symbol Pdgfrb
Entrez Gene 24629
Alt Symbol PDGFR-1
Species Rat
Gene Type protein-coding
Description platelet derived growth factor receptor, beta polypeptide
Other Description CD140 antigen-like family member B|PDGF-R-beta|PDGFR-beta|Platelet-derived growth factor receptor, beta|beta platelet-derived growth factor receptor|beta-type platelet-derived growth factor receptor|platelet-derived growth factor receptor 1|platelet-derived growth factor receptor beta|platelet-derived growth factor receptor beta variant 1
Swissprots Q925F7 Q05030 Q8R406
Accessions EDM14586 Q05030 AF359356 AAK43716 AY090783 AAM09098 DQ979389 ABJ53143 Z14119 CAA78489 XM_006254789 XP_006254851 XM_008772084 XP_008770306 NM_031525 NP_113713
Function Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. Plays a role in the migration of vascular smooth muscle cells and the formation of neointima at vascular injury sites. Required for normal development of the cardiovascular system. Required for normal recruitment of pericytes (mesangial cells) in the kidney glomerulus, and for normal formation of a branched network of capillaries in kidney glomeruli. Promotes rearrangement of the actin cytoskeleton and the formation of membrane ruffles. Binding of its cognate ligands - homodimeric PDGFB, heterodimers formed by PDGFA and PDGFB or homodimeric PDGF
Subcellular Location Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Lysosome lumen {ECO:0000250}. Note=After ligand binding, the autophosphorylated receptor is ubiquitinated and internalized, leading to its degradation. {ECO:0000250}.
Top Pathways Rap1 signaling pathway, MicroRNAs in cancer, Central carbon metabolism in cancer, Choline metabolism in cancer, Cytokine-cytokine receptor interaction

Rat PDGFRB protein - orb139461 from Biorbyt

Category Protein
Prices $298.00, $400.00
Sizes 50 μg, 100 μg
Source Human Cells
Species Rat
SDS-PAGE analysis of Rat PDGFRB protein

Rat PDGFRB protein (His Tag) - orb139460 from Biorbyt

Category Protein
Prices $434.00, $612.00
Sizes 100 μg, 200 μg
Source Human Cells
Species Rat
SDS-PAGE analysis of Rat PDGFRB protein (His Tag)

Recombinant Rat Pdgfrb, His tagged - Pdgfrb-8786R from Creative Biomart

Category Protein
Source Human Cells
Species Rat

Recombinant Rat Pdgfrb, Fc tagged - Pdgfrb-36R from Creative Biomart

Category Protein
Source Human Cells
Species Rat

Rat PDGFR beta Recombinant - RKQ05030 from Reprokine

Category Protein
Prices $160.00, $550.00, $1,950.00
Sizes 50 µg, 200 µg, 1 mg
Source Optimized DNA sequence encoding extracellular domain of rat PDGFR beta ncluding a C-terminal 6His tag was expressed in HEK293 cells.
Species Rat

Rat PDGFRB / PDGFR-1 Protein (His Tag) - 80347-R08H-100 from Sino Biological

Category Protein
Prices $198.00, $298.00
Sizes 100 µg, 200 µg
Source Human Cells
Species Rat

Rat PDGFRB / PDGFR-1 Protein (Fc Tag) - 80347-R02H-50 from Sino Biological

Category Protein
Prices $108.00, $178.00
Sizes 50 µg, 100 µg
Source Human Cells
Species Rat

PDGFR beta, Recombinant Protein - MBS553313 from MyBioSource

Category Protein
Prices $220.00, $595.00, $2,220.00
Sizes 50 µg, 200 µg, 1 mg

Platelet Derived Growth Factor Receptor Beta, Recombinant Protein - MBS2030725 from MyBioSource

Category Protein
Prices $185.00, $385.00, $595.00
Sizes 10 µg, 50 µg, 100 µg
Source Prokaryotic expression

Recombinant Rat PDGFRB / PDGFR-1 Protein (His tag) - PKSR030212 from Elabscience

Category Protein
Source Human Cell
Species Rat

Recombinant Rat PDGFRB / PDGFR-1 Protein (Fc tag) - PKSR030213 from Elabscience

Category Protein
Source Human Cell
Species Rat

Recombinant Rat PDGFRB Protein - PDGFRB-4340R from Creative Biomart

Category Protein
Source Mammalian Cells
Species Rat

Rat PDGFRB / PDGFR-1 Protein (Fc Tag) - 80347-R02H from ABclonal

Category Protein
Prices $108.00, $178.00
Sizes 50 µg, 100 µg
Source Human Cells
Species Rat

Rat PDGFRB / PDGFR-1 Protein (His Tag) - 80347-R08H from ABclonal

Category Protein
Prices $198.00, $298.00
Sizes 100 µg, 200 µg
Source Human Cells
Species Rat

PDGFRB / PDGFR-1, Recombinant Protein - MBS2547327 from MyBioSource

Category Protein
Prices $525.00, $775.00
Sizes 100 µg, 200 µg
Source Human Cells

PDGFRB / PDGFR-1, Recombinant Protein - MBS2547328 from MyBioSource

Category Protein
Prices $295.00, $475.00
Sizes 50 µg, 100 µg
Source Human Cells
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