ATP2A2

Gene Symbol	ATP2A2
Entrez Gene	488
Alt Symbol	ATP2B, DAR, DD, SERCA2
Species	Human
Gene Type	protein-coding
Description	ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Other Description	ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2|SR Ca(2+)-ATPase 2|calcium pump 2|calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform|cardiac Ca2+ ATPase|endoplasmic reticulum class 1/2 Ca(2+) ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Swissprots	P16615 Q86VJ2 P16614 A6NDN7 B4DF05
Accessions	AAA52757 AAA52758 ABY71268 ACA51040 EAW97902 EAW97903 EAW97904 EAW97905 EAW97906 EAW97907 P16615 AK000300 AK095382 AK293877 BAG57266 AL117505 AY186578 AAO47398 BC035588 AAH35588 BC065753 BG773489 BI553880 BX648282 M23114 AAA53193 M23115 AAA53194 XM_005253888 XP_005253945 XM_011538402 XP_011536704 XM_011538403 XP_011536705 XR_243009 NM_001681 NP_001672 NM_170665 NP_733765 NM_001135765
Function	This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. {ECO:0000269|PubMed:16402920}.
Subcellular Location	Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity	Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. {ECO:0000269|PubMed:10441324, ECO:0000269|PubMed:12659872, ECO:0000269|PubMed:16402920}.
Top Pathways	cAMP signaling pathway, Alzheimer's disease, cGMP-PKG signaling pathway, Adrenergic signaling in cardiomyocytes, Pancreatic secretion

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ATP2A2 / SERCA2 ELISA Kit (Sandwich ELISA) - LS-F6830 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.113 ng/ml Range 0.313-20 ng/ml

Mouse ATP2A2 / SERCA2 ELISA Kit (Sandwich ELISA) - LS-F7345 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.058 ng/ml Range 0.313-20 ng/ml

Human ATP2A2 ELISA Kit - abx150769 from Abbexa Category ELISA Kit Sensitivity 0.126 ng/ml Range 0.313 ng/ml - 20 ng/ml

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2), Human, ELISA Kit - SEG374Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 0.126ng/mL Range 0.312-20ng/mL

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), Human, ELISA Kit - E01S0330 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2, ELISA Kit - MBS099658 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2, ELISA Kit - MBS062584 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2, ELISA Kit - MBS083898 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2, ELISA Kit - MBS081864 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2, ELISA Kit - MBS053960 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2, ELISA Kit - MBS056536 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2, ELISA Kit - MBS048369 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2), ELISA Kit - MBS2019157 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.056ng/mL. Range 0.156-10ng/mL.

ATPase, Ca++ Transporting, Cardiac Muscle, Slow Twitch 2 (ATP2A2), ELISA Kit - MBS2019773 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.121ng/mL. Range 0.313-20ng/mL

HK2, ELISA Kit - MBS2515866 from MyBioSource Category ELISA Kit Prices $410.00, $490.00, $2,040.00, $3,590.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 75pg/mL Range 125-8000pg/mL

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7252760 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7218485 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7201603 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7210052 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7241595 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7253381 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7215782 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7241925 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7216867 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 (ATP2A2), ELISA Kit - MBS7243491 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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