Gene Symbol ATP2A2
Entrez Gene 488
Alt Symbol ATP2B, DAR, DD, SERCA2
Species Human
Gene Type protein-coding
Description ATPase, Ca++ transporting, cardiac muscle, slow twitch 2
Other Description ATPase, Ca++ dependent, slow-twitch, cardiac muscle-2|SR Ca(2+)-ATPase 2|calcium pump 2|calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform|cardiac Ca2+ ATPase|endoplasmic reticulum class 1/2 Ca(2+) ATPase|sarcoplasmic/endoplasmic reticulum calcium ATPase 2
Swissprots P16615 Q86VJ2 P16614 A6NDN7 B4DF05
Accessions AAA52757 AAA52758 ABY71268 ACA51040 EAW97902 EAW97903 EAW97904 EAW97905 EAW97906 EAW97907 P16615 AK000300 AK095382 AK293877 BAG57266 AL117505 AY186578 AAO47398 BC035588 AAH35588 BC065753 BG773489 BI553880 BX648282 M23114 AAA53193 M23115 AAA53194 XM_005253888 XP_005253945 XM_011538402 XP_011536704 XM_011538403 XP_011536705 XR_243009 NM_001681 NP_001672 NM_170665 NP_733765 NM_001135765
Function This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform 2 is involved in the regulation of the contraction/relaxation cycle. {ECO:0000269|PubMed:16402920}.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein. Sarcoplasmic reticulum membrane; Multi-pass membrane protein.
Tissue Specificity Isoform 1 is widely expressed in smooth muscle and nonmuscle tissues such as in adult skin epidermis, with highest expression in liver, pancreas and lung, and intermediate expression in brain, kidney and placenta. Also expressed at lower levels in heart and skeletal muscle. Isoforms 2 and 3 are highly expressed in the heart and slow twitch skeletal muscle. Expression of isoform 3 is predominantly restricted to cardiomyocytes and in close proximity to the sarcolemma. Both isoforms are mildly expressed in lung, kidney, liver, pancreas and placenta. Expression of isoform 3 is amplified during monocytic differentiation and also observed in the fetal heart. {ECO:0000269|PubMed:10441324, ECO:0000269|PubMed:12659872, ECO:0000269|PubMed:16402920}.
Top Pathways cAMP signaling pathway, Alzheimer's disease, cGMP-PKG signaling pathway, Adrenergic signaling in cardiomyocytes, Pancreatic secretion

ATP2A2 293 Cell Lysate - 404029 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg
Tissue Muscle

SERCA2 ATPase Overexpression Lysate (Native) - NBP2-05184 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: SERCA2 ATPase Overexpression Lysate (Adult Normal) [NBP2-05184] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SERCA2 ATPase.

ATP2A2 Over-expression Lysate Product - GWB-A794A9 from Genway Biotech

Category Cell Lysate
Prices $445.00
Sizes 100 µg
Species Human

Panoply™ Human ATP2A2 Knockdown Stable Cell Line - CSC-DC001142 from Creative biogene

Category Cell Line
Species Human
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