UBA1

Gene Symbol UBA1
Entrez Gene 7317
Alt Symbol A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X
Species Human
Gene Type protein-coding
Description ubiquitin-like modifier activating enzyme 1
Other Description A1S9T and BN75 temperature sensitivity complementing|POC20 centriolar protein homolog|UBA1, ubiquitin-activating enzyme E1 homolog A|ubiquitin-like modifier-activating enzyme 1
Swissprots P22314 Q96E13 Q5JRR8
Accessions CAA05866 EAW59290 EAW59291 EAW59292 EAW59293 P22314 AF258566 AAG23769 AK097343 BAG53454 AK131341 AK293161 BAG56705 AK296866 BAG59429 BC009900 BC013041 AAH13041 BC020261 BG703038 BI547207 EU176375 ABW03826 EU176712 ABW03513 M58028 AAA61246 X52897 CAA37078 X56976 CAA40296 XM_005272649 XP_005272706 XM_005272650 XP_005272707 XM_011543953 XP_011542255 XM_011543954 XP_011542256 XM_011543955 XP_011542257 XM_011543956 XP_011542258 NM_003334 NP_003325 NM_153280 NP_695012
Function Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system. Activates ubiquitin by first adenylating its C- terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. {ECO:0000269|PubMed:22456334}.
Subcellular Location Isoform 2: Cytoplasm.
Top Pathways Ubiquitin mediated proteolysis

UBE1a/b Antibody - 4891 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562 and SK-N-MC cells using UBE1a/b Antibody.

UBE1a Antibody - 4890 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from K562 and SK-N-MC cells using UBE1a Antibody.

UBE1 (B-5) - sc-271821 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE1 (B-5): sc-271821. Western blot analysis of UBE1 expression in non-transfected: sc-117752 (A) and human UBE1 transfected: sc-171710 (B) 293T whole cell lysates.

UBE1 (C-15) - sc-47552 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UBE1 (C-15): sc-47552. Western blot analysis of UBE1 expression in non-transfected: sc-117752 (A) and human UBE1 transfected: sc-171710 (B) 293T whole cell lysates.

UBE1 (N-20) - sc-47555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
UBE1 (N-20): sc-47555. Western blot analysis of UBE1 expression in HeLa nuclear extract.

UBE1 (N-19) - sc-47554 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

UBE1 (2G2) - sc-53555 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
UBE1 (2G2): sc-53555. Immunofluorescence staining of methanol-fixed HeLa cells showing nuclear localization.

UBE1 (H-114) - sc-292773 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
UBE1 (H-114): sc-292773. Western blot analysis of UBE1 expression in non-transfected: sc-117752 (A) and human UBE1 transfected: sc-171710 (B) 293T whole cell lysates.

Anti-E1 Ubiquitin Activating Enzyme antibody - ab34711 from Abcam

Prices $387.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal
This image shows human lung tissue stained with ab34711 at 10µg/ml.  In many cells apunctate nuclear staining was observed. Other cells showed both cytoplasmic and nuclear staining.

Anti-E1 Ubiquitin Activating Enzyme antibody - ab123346 from Abcam

Prices $376.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-E1 Ubiquitin Activating Enzyme antibody (ab123346) at 1/100 dilution + K562 cell line lysates at 35 µg

Anti-E1 Ubiquitin Activating Enzyme antibody [EPR14203(B)] - ab180125 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14203(B)
Flow cytometric analysis of 2% paraformaldehyde-fixed K562 cells labeling E1 Ubiquitin Activating Enzyme with ab180125 at 1/70 dilution (red) compared to a rabbit IgG control (green), followed by Goat anti rabbit IgG (FITC) secondary antibody at 1/75 dilution.

Anti-E1 Ubiquitin Activating Enzyme antibody [EPR14204(B)] - ab181225 from Abcam

Prices $384.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR14204(B)
All lanes : Anti-E1 Ubiquitin Activating Enzyme antibody [EPR14204(B)] (ab181225) at 1/10000 dilutionLane 1 : Human fetal brain lysateLane 2 : K562 cell lysateLane 3 : HeLa cell lysateLane 4 : Jurkat cell lysateLysates/proteins at 20 µg per lane.SecondaryGoat Anti-Rabbit IgG, (H+L), Peroxidase conjugate at 1/1000 dilution

Anti-E1 Ubiquitin Activating Enzyme antibody - C-terminal - ab195425 from Abcam

Prices $370.00
Sizes 25 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody - LS-C93218 from LifeSpan Bioscience

Prices $485.00
Sizes 250 µg
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (N-Terminus) - LS-C40071 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (aa1-50) - LS-C93219 from LifeSpan Bioscience

Prices $545.00
Sizes 20 µg
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (aa753-1006) - LS-C185402 from LifeSpan Bioscience

Prices $245.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (aa1-30, AP) - LS-C272825 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (aa1-30, APC) - LS-C272826 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (aa1-30, Biotin) - LS-C272827 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (aa1-30, FITC) - LS-C272828 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (aa1-30, Azide-free, HRP) - LS-C272829 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (aa1-30, PE) - LS-C272830 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (C-Terminus, APC) - LS-C283971 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-UBA1 / UBE1 Antibody (C-Terminus, AP) - LS-C283970 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Search more