UBA1

Gene Symbol	UBA1
Entrez Gene	7317
Alt Symbol	A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like modifier activating enzyme 1
Other Description	A1S9T and BN75 temperature sensitivity complementing|POC20 centriolar protein homolog|UBA1, ubiquitin-activating enzyme E1 homolog A|ubiquitin-like modifier-activating enzyme 1
Swissprots	P22314 Q96E13 Q5JRR8
Accessions	CAA05866 EAW59290 EAW59291 EAW59292 EAW59293 P22314 AF258566 AAG23769 AK097343 BAG53454 AK131341 AK293161 BAG56705 AK296866 BAG59429 BC009900 BC013041 AAH13041 BC020261 BG703038 BI547207 EU176375 ABW03826 EU176712 ABW03513 M58028 AAA61246 X52897 CAA37078 X56976 CAA40296 XM_005272649 XP_005272706 XM_005272650 XP_005272707 XM_011543953 XP_011542255 XM_011543954 XP_011542256 XM_011543955 XP_011542257 XM_011543956 XP_011542258 NM_003334 NP_003325 NM_153280 NP_695012
Function	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system. Activates ubiquitin by first adenylating its C- terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. {ECO:0000269|PubMed:22456334}.
Subcellular Location	Isoform 2: Cytoplasm.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

UBA1 293 Cell Lysate - 404119 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

UBA1 293 Cell Lysate - 408758 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Ubiquitin-activating Enzyme/UBE1 Overexpression Lysate (Native) - NBL1-17495 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Ubiquitin-activating Enzyme/UBE1 Overexpression Lysate (Native) - NBL1-17494 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

UBE1 (h): 293T Lysate - sc-171710 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

UBA1 Over-expression Lysate Product - GWB-7E14CC from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

UBA1 Over-expression Lysate Product - GWB-6E0EE0 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Human UBE1 / UBA1 Insect Cell Lysate (WB positive control) - 11990-H20BL-300 from Sino Biological Category Cell Lysate Prices $195.00 Sizes 300 µg Species Human

Human UBE1 Baculovirus-Insect Cells Transfected Lysate (positive control) (denatured) - orb175186 from Biorbyt Category Cell Lysate Prices $604.00 Sizes 300 μg Species Human

Panoply™ Human UBA1 Knockdown Stable Cell Line - CSC-DC016929 from Creative biogene Category Cell Line Species Human

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