UBA1

Gene Symbol	UBA1
Entrez Gene	7317
Alt Symbol	A1S9, A1S9T, A1ST, AMCX1, CFAP124, GXP1, POC20, SMAX2, UBA1A, UBE1, UBE1X
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like modifier activating enzyme 1
Other Description	A1S9T and BN75 temperature sensitivity complementing|POC20 centriolar protein homolog|UBA1, ubiquitin-activating enzyme E1 homolog A|ubiquitin-like modifier-activating enzyme 1
Swissprots	P22314 Q96E13 Q5JRR8
Accessions	CAA05866 EAW59290 EAW59291 EAW59292 EAW59293 P22314 AF258566 AAG23769 AK097343 BAG53454 AK131341 AK293161 BAG56705 AK296866 BAG59429 BC009900 BC013041 AAH13041 BC020261 BG703038 BI547207 EU176375 ABW03826 EU176712 ABW03513 M58028 AAA61246 X52897 CAA37078 X56976 CAA40296 XM_005272649 XP_005272706 XM_005272650 XP_005272707 XM_011543953 XP_011542255 XM_011543954 XP_011542256 XM_011543955 XP_011542257 XM_011543956 XP_011542258 NM_003334 NP_003325 NM_153280 NP_695012
Function	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin- proteasome system. Activates ubiquitin by first adenylating its C- terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP. Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites. {ECO:0000269|PubMed:22456334}.
Subcellular Location	Isoform 2: Cytoplasm.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human E1 Ubiquitin Activating Enzyme full length protein - ab125733 from Abcam Category Protein Source E. coli Species Human

Active human E1 Ubiquitin Activating Enzyme full length protein - ab188686 from Abcam Category Protein Prices $365.00 Sizes 50 µg Source Baculovirus infected Sf21 cells Species Human

E1 Ubiquitin Activating Enzyme protein (Tagged) - Chemical Free - ab80726 from Abcam Category Protein Prices $439.00 Sizes 50 µg Source Baculovirus infected sf9 cells Species Human

Human E1 Ubiquitin Activating Enzyme full length protein - ab179958 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

UBA1 / UBE1 Antibody Blocking Peptide - LS-E3381 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBA1 / UBE1 Antibody Blocking Peptide - LS-E6861 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

UBA1 / UBE1 Antibody Blocking Peptide - LS-E21477 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Ubiquitin-activating Enzyme/UBE1 Protein - H00007317-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Ubiquitin-activating Enzyme/UBE1 Protein - H00007317-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Ubiquitin-activating Enzyme/UBE1 Peptide - P0884 from Novus Biologicals Category Peptide Species Human

UBA1-Antibody-N-term-Blocking-Peptide - BP14555a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

E1-Ubiquitin-UBE1-Antibody-C-term-Blocking-peptide - BP2113b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant Human Ubiquitin Activating Enzyme (UBE1), CF - E-305-025 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived,

Recombinant Human His6-Ubiquitin E1 Enzyme (UBE1), CF - E-304-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 21 (baculovirus)-derived, Contains an N-terminal Met-Ser-Tyr-Tyr and 6-His tag

Recombinant Human GST-Ubiquitin E1 Enzyme (UBE1), CF - E-306-050 from R&D Systems Category Protein Source Spodoptera frugiperda, Sf 9 (baculovirus)-derived, Contains an N-terminal GST (glutathione S-transferase) tag

Human UBA1 protein (GST Tag) - orb139833 from Biorbyt Category Protein Prices $298.00, $434.00 Sizes 20 μg, 50 μg Source Baculovirus-Insect Cells Species Human

UBA1 Blocking Peptide - 33R-5889 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

UBE1 / UBA1 - H00007317-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

UBE1 / UBA1 - H00007317-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

UBE1 / UBA1 - H00007317-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

UBE1 / UBA1 - H00007317-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

UBE1 fusion protein - Ag8920 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

UBE1 fusion protein - ag8703 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant UBA1 protein - 31227 from ActiveMotif Category Protein Prices $390.00 Sizes 10 µg Source E. coli Species Human

UBE1 (UBA1), Active Human Recombinant Protein - GWB-ACB42F from Genway Biotech Category Protein Prices $392.00 Sizes 100 µg Species Human

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