| Gene Symbol | C8A |
|---|---|
| Entrez Gene | 731 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | complement component 8, alpha polypeptide |
| Other Description | complement component 8 subunit alpha|complement component C8 alpha chain |
| Swissprots | Q13668 A2RUI4 P07357 A2RUI5 Q9H130 |
| Accessions | AAA82124 EAX06644 EAX06645 EAX06646 P07357 AK309596 BC020702 AAH20702 BC132911 AAI32912 BC132913 AAI32914 HQ258328 ADR83082 M16974 AAA52200 XM_011542079 XP_011540381 NM_000562 NP_000553 |
| Function | Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C8A inserts into the target membrane, but does not form pores by itself. {ECO:0000269|PubMed:17872444, ECO:0000269|PubMed:7440581}. |
| Subcellular Location | Secreted. Cell membrane; Multi-pass membrane protein. Note=Secreted as soluble protein. Inserts into the cell membrane of target cells. |
| Top Pathways | Complement and coagulation cascades, Systemic lupus erythematosus, Prion diseases, Amoebiasis |