RELA

Gene Symbol	RELA
Entrez Gene	5970
Alt Symbol	NFKB3, p65
Species	Human
Gene Type	protein-coding
Description	v-rel avian reticuloendotheliosis viral oncogene homolog A
Other Description	NF-kappa-B p65delta3|nuclear factor NF-kappa-B p65 subunit|nuclear factor of kappa light polypeptide gene enhancer in B-cells 3|transcription factor p65|v-rel reticuloendotheliosis viral oncogene homolog A
Swissprots	Q04206 Q6GTV1 Q6SLK1
Accessions	AAR13863 CAA80524 CCO13802 EAW74424 EAW74425 EAW74426 Q04206 AK303262 BAG64344 AK308020 AK308478 BC011603 AAH11603 BC014095 AAH14095 BC033522 AAH33522 BC069248 BC110830 AAI10831 BM916512 BU633061 DA020095 L19067 AAA20946 M62399 AAA36408 U33838 AAA92888 U88316 AAB48487 XM_011545206 XP_011543508 XM_011545207 XP_011543509 NM_001145138 NP_001138610 NM_001243984 NP_001230913 NM_001243985 NP_001230914 NM_021975 NP_068810
Function	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with ot
Subcellular Location	Nucleus. Cytoplasm. Note=Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation. {ECO:0000250}.
Top Pathways	Sphingolipid signaling pathway, Apoptosis, Herpes simplex infection, Prolactin signaling pathway, Legionellosis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® NF-κB p65 siRNA I - 6261 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (50-100 transfections) Species Reactivities Human

SignalSilence ® NF-κB p65 siRNA II - 6534 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

NFκB p65 siRNA (h) - sc-29410 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NFκB p65 shRNA Plasmid (h) - sc-29410-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NFκB p65 shRNA (h) Lentiviral Particles - sc-29410-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NFκB p65 siRNA (h2) - sc-44212 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NFκB p65 shRNA Plasmid (h2) - sc-44212-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

NFκB p65 shRNA (h2) Lentiviral Particles - sc-44212-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RelA/NFkB p65 RNAi - H00005970-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU141461 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN1470 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1526 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit - CKOZFN1469 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1469 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1470 from Sigma-Aldrich Category ZFN Kit Prices $4,120.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1526 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

RELA siRNA (Human) - CRH4040 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RELA - MBS8224617 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RELA (NM_021975.3) - SHH391800 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RELA(NM_001145138.1) - SHR175438 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RELA(NM_001243984.1) - SHR175494 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RELA(NM_001243985.1) - SHR175530 from Creative biogene Category siRNA Species Reactivities Human

RELA shRNA Plasmid (Human) - CHH4040 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RELA miRNA 3'UTR clone - MiUTR1H-08731 from Creative biogene Species Reactivities Human

RELA miRNA 3'UTR clone - MiUTR1H-08732 from Creative biogene Species Reactivities Human

Search more