NOTCH1

Gene Symbol	NOTCH1
Entrez Gene	4851
Alt Symbol	AOS5, AOVD1, TAN1, hN1
Species	Human
Gene Type	protein-coding
Description	notch 1
Other Description	Notch homolog 1, translocation-associated|neurogenic locus notch homolog protein 1|translocation-associated notch protein TAN-1
Swissprots	P46531 Q59ED8 Q5SXM3
Accessions	AFA51166 AFA51167 AFD02281 AFD64628 AHH85782 AHJ25884 CBX47648 CCQ43558 EAW88241 P46531 AB209873 BAD93110 AF308602 AAG33848 AK000012 BAA90883 BC013208 BC039147 BC046127 BC049843 BC063597 CN431067 CR457221 CAG33502 DA324222 M73980 AAA60614 XM_011518717 XP_011517019 NM_017617 NP_060087
Function	Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved
Subcellular Location	Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues.
Top Pathways	Notch signaling pathway, Prion diseases, MicroRNAs in cancer, Dorso-ventral axis formation

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PathScan ® Cleaved Notch1 (Val1744) Sandwich ELISA Kit - 7194 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

PathScan ® Total Notch1 Sandwich ELISA Kit - 7245 from Cell Signaling Technology Category ELISA Kit Prices $489.00 Sizes 1 kit (96 assays)

Notch-1 (TAN-1) Human ELISA Kit - ab155437 from Abcam Category ELISA Kit Prices $489.00 Sizes 1 x 96 tests Sensitivity < 20 pg/ml Range 0.029 ng/ml - 7 ng/ml

Human NOTCH1 ELISA Kit (Sandwich ELISA) - LS-F167 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 20 pg/ml Range 20-7000 pg/ml

Human NOTCH1 ELISA Kit (Sandwich ELISA) - LS-F1005 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 20-7000 pg/ml

Human NOTCH1 ELISA Kit (Sandwich ELISA) - LS-F12173 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 78 Range 20-7000 pg/ml

Rabbit anti-Notch1 Antibody, Affinity Purified - PLA0222 from Sigma-Aldrich Prices $323.50 Sizes 100 µl

Human Notch-1 ELISA Kit - RAB0384 from Sigma-Aldrich Category ELISA Kit Prices $423.50 Sizes 1 kt

Human Notch-1 DuoSet ELISA - DY5317 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 78.10 - 5,000 pg/mL

Notch-1 ELISA Kit (Human) : 96 Wells (OKAG00156) - OKAG00156 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 79 pg/mL Range 79-5,000 pg/mL

Neurogenic locus notch homolog protein 1 (NOTCH1), Human, ELISA Kit - CSB-EL015949HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Neurogenic locus notch homolog protein 1, NOTCH1, Human, ELISA Kit - E0501h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 78-5000 pg/mL

NOTCH1 (Human) ELISA Kit - KA2219 from Acris Antibodies Category ELISA Kit Prices $650.00 Sizes 1 kit

Human NOTCH-1 ELISA - ELH-NOTCH1 from RayBiotech Category ELISA Kit Prices $390.00, $702.00, $1,561.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 20 pg/ml Range 20 pg/ml - 7000 pg/ml

Notch-1 (Human) OmniKine™ ELISA Kit - OK-0257 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range 79-5000 pg/ml

NOTCH1 (Human) ELISA Kit - DEIA3986 from Creative Diagnostics Category ELISA Kit Sensitivity The antigens were tested at 50 ng/mL.

Human Notch-1 ELISA Kit - DEIA5700 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of Notch-1 is typically less than 20 pg/mL.

Neurogenic locus notch homolog protein 1, NOTCH1, ELISA Kit - MBS9306642 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0ng/ml Range 3.12ng/ml-100ng/ml

Neurogenic locus notch homolog protein 1, NOTCH1, ELISA Kit - MBS9307155 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Notch homolog 1, translocation-associated (Drosophila) , ELISA Kit - MBS918395 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <3.9 pg/ml Range 15.6 pg/ml-1000 pg/ml

Human Neurogenic locus notch homolog protein 1(NOTCH1) ELISA kit - CSB-EL015949HU from Cusabio Category ELISA Kit Sensitivity 19.5 pg/ml Range 78 pg/ml-5000 pg/ml

Notch-1 (human) ELISA Kit - K4763-100 from Biovision Category ELISA Kit Prices $695.00 Sizes 100 assays

Mouse NOTCH1 ELISA Kit (Custom ELISA) - LS-F14664 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 20-7000 pg/ml

Rat NOTCH1 ELISA Kit (Custom ELISA) - LS-F14665 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 20-7000 pg/ml

Notch-1, ELISA Kit - MBS843478 from MyBioSource Category ELISA Kit Prices $865.00 Sizes 100 assays

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