NOTCH1
| Gene Symbol | NOTCH1 |
|---|---|
| Entrez Gene | 4851 |
| Alt Symbol | AOS5, AOVD1, TAN1, hN1 |
| Species | Human |
| Gene Type | protein-coding |
| Description | notch 1 |
| Other Description | Notch homolog 1, translocation-associated|neurogenic locus notch homolog protein 1|translocation-associated notch protein TAN-1 |
| Swissprots | P46531 Q59ED8 Q5SXM3 |
| Accessions | AFA51166 AFA51167 AFD02281 AFD64628 AHH85782 AHJ25884 CBX47648 CCQ43558 EAW88241 P46531 AB209873 BAD93110 AF308602 AAG33848 AK000012 BAA90883 BC013208 BC039147 BC046127 BC049843 BC063597 CN431067 CR457221 CAG33502 DA324222 M73980 AAA60614 XM_011518717 XP_011517019 NM_017617 NP_060087 |
| Function | Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs. Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting. Involved in the maturation of both CD4+ and CD8+ cells in the thymus. Important for follicular differentiation and possibly cell fate selection within the follicle. During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia. Represses neuronal and myogenic differentiation. May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation. May be involved |
| Subcellular Location | Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. |
| Tissue Specificity | In fetal tissues most abundant in spleen, brain stem and lung. Also present in most adult tissues where it is found mainly in lymphoid tissues. |
| Top Pathways | Notch signaling pathway, Prion diseases, MicroRNAs in cancer, Dorso-ventral axis formation |
Notch 1 CRISPR/Cas9 KO Plasmid (h) - sc-400167 from Santa Cruz Biotechnology
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Notch 1 HDR Plasmid (h) - sc-400167-HDR from Santa Cruz Biotechnology
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Notch 1 Double Nickase Plasmid (h) - sc-400167-NIC from Santa Cruz Biotechnology
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Notch 1 Double Nickase Plasmid (h2) - sc-400167-NIC-2 from Santa Cruz Biotechnology
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Notch 1 CRISPR Activation Plasmid (h) - sc-400167-ACT from Santa Cruz Biotechnology
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Notch 1 CRISPR Activation Plasmid (h2) - sc-400167-ACT-2 from Santa Cruz Biotechnology
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Notch 1 Lentiviral Activation Particles (h) - sc-400167-LAC from Santa Cruz Biotechnology
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Notch 1 Lentiviral Activation Particles (h2) - sc-400167-LAC-2 from Santa Cruz Biotechnology
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Notch 1 siRNA (h) - sc-36095 from Santa Cruz Biotechnology
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Notch 1 shRNA Plasmid (h) - sc-36095-SH from Santa Cruz Biotechnology
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Notch 1 shRNA (h) Lentiviral Particles - sc-36095-V from Santa Cruz Biotechnology
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Notch 1 siRNA (h2) - sc-44226 from Santa Cruz Biotechnology
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Notch 1 shRNA Plasmid (h2) - sc-44226-SH from Santa Cruz Biotechnology
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Notch 1 shRNA (h2) Lentiviral Particles - sc-44226-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU150431 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1460 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1461 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1171 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1460 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1461 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09849 from Sigma-Aldrich
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NOTCH1 siRNA (Human) - CRH3223 from Cohesion Biosciences
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Notch-1 RNAi - H00004851-R01 from Novus Biologicals
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shRNA set against Human NOTCH1(NM_017617.3) - SHH218005 from Creative biogene
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