ALK

Gene Symbol	ALK
Entrez Gene	238
Alt Symbol	CD246, NBLST3
Species	Human
Gene Type	protein-coding
Description	anaplastic lymphoma receptor tyrosine kinase
Other Description	ALK tyrosine kinase receptor|CD246 antigen|mutant anaplastic lymphoma kinase
Swissprots	Q9UM73 Q4ZFX9 Q9Y4K6 Q59FI3 Q53RZ4 Q53QQ6
Accessions	AAX76514 AAX88892 AAX93126 AAY15027 ACD03579 ACD03580 ACD03581 ACD03582 ACD03583 ACD03584 ACD03585 ACD03586 ACD03587 ACD03588 ACD03589 CAT16962 CCV20015 EAX00506 EAX00507 EAX00508 Q9UM73 AB209477 BAD92714 AK296218 BAG58942 BC156207 AAI56208 BC157090 AAI57091 DA455128 EU788003 ACI47591 EU788004 ACI47592 EU788005 ACI47593 EU788006 ACI47594 EU788007 ACI47595 EU788008 ACI47596 EU788009 ACI47597 EU788010 ACI47598 FJ838786 ACZ57900 FJ838787 ACZ57901 GU128152 ACY79560 GU128153 ACY79561 GU128154 ACY79562 GU128155 ACY79563 GU128156 ACY79564 GU128157 ACY79565 U62540 AAB71619 U66559 AAC51104 NM_004304 NP_004295
Function	Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor s
Subcellular Location	Cell membrane {ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:9174053}; Single-pass type I membrane protein {ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:9174053}. Note=Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.
Tissue Specificity	Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells. {ECO:0000269|PubMed:9174053}.
Top Pathways	Non-small cell lung cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ALK (mutated C1156 Y) protein fragment - ab191035 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human ALK (mutated F1174 L) protein fragment - ab186454 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human ALK (mutated R1275 Q) protein fragment - ab186455 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human ALK protein fragment - ab187246 from Abcam Category Protein Prices $436.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human ALK protein fragment - ab186464 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Insect cells Species Human

Active human ALK protein fragment - ab186465 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Insect cells Species Human

Active human ALK protein fragment - ab198110 from Abcam Category Protein Prices $891.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human ALK protein fragment - ab186458 from Abcam Category Protein Prices $521.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Human ALK protein fragment - ab38128 from Abcam Category Protein Prices $297.00 Sizes 10 µg Source E. coli Species Human

ALK-Antibody-N-term-Blocking-peptide - BP11211a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALK-Antibody-C-term-Y1604-Blocking-peptide - BP11629c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALK-Antibody-Center-Blocking-Peptide - BP7600c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ALK/P80 Protein (OPPA01362) - OPPA01362 from Aviva Systems Biology Category Protein Prices $315.00 Sizes 2 µg Source E. Coli

ALK protein - orb197713 from Biorbyt Category Protein Prices $425.00 Sizes 100 μg Species Human

Human ALK/P80 protein - orb80908 from Biorbyt Category Protein Prices $366.00, $400.00, $612.00 Sizes 5 μg, 2 μg, 10 μg Species Human

Human ALK protein - orb78498 from Biorbyt Category Protein Prices $255.00, $391.00 Sizes 10 μg, 50 μg Species Human

ALK protein - orb197714 from Biorbyt Category Protein Prices $366.00 Sizes 100 μg Species Human

Goat anti Alk antibody Immunizing peptide - orb66250 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

ALK Blocking Peptide - 33R-10471 from Fitzgerald Category Peptide Prices $295.00 Sizes 50 µg

ALK Blocking Peptide - 33R-10723 from Fitzgerald Category Peptide Prices $145.00 Sizes 50 µg

CD246 Blocking Peptide - abx062019 from Abbexa Category Peptide Species Human, Mouse, Rat, Bovine, Dog, Monkey, Pig

ALK Peptide - AC21-2549-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

CD246 / Anaplastic lymphoma kinase - H00000238-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

CD246 / Anaplastic lymphoma kinase - H00000238-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

CD246 / Anaplastic lymphoma kinase - P4644 from Acris Antibodies Category Protein Prices $1,380.00 Sizes 100 µg Species Human

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