ALK

Gene Symbol ALK
Entrez Gene 238
Alt Symbol CD246, NBLST3
Species Human
Gene Type protein-coding
Description anaplastic lymphoma receptor tyrosine kinase
Other Description ALK tyrosine kinase receptor|CD246 antigen|mutant anaplastic lymphoma kinase
Swissprots Q9UM73 Q4ZFX9 Q9Y4K6 Q59FI3 Q53RZ4 Q53QQ6
Accessions AAX76514 AAX88892 AAX93126 AAY15027 ACD03579 ACD03580 ACD03581 ACD03582 ACD03583 ACD03584 ACD03585 ACD03586 ACD03587 ACD03588 ACD03589 CAT16962 CCV20015 EAX00506 EAX00507 EAX00508 Q9UM73 AB209477 BAD92714 AK296218 BAG58942 BC156207 AAI56208 BC157090 AAI57091 DA455128 EU788003 ACI47591 EU788004 ACI47592 EU788005 ACI47593 EU788006 ACI47594 EU788007 ACI47595 EU788008 ACI47596 EU788009 ACI47597 EU788010 ACI47598 FJ838786 ACZ57900 FJ838787 ACZ57901 GU128152 ACY79560 GU128153 ACY79561 GU128154 ACY79562 GU128155 ACY79563 GU128156 ACY79564 GU128157 ACY79565 U62540 AAB71619 U66559 AAC51104 NM_004304 NP_004295
Function Neuronal orphan receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor s
Subcellular Location Cell membrane {ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:9174053}; Single-pass type I membrane protein {ECO:0000269|PubMed:16317043, ECO:0000269|PubMed:9174053}. Note=Membrane attachment was crucial for promotion of neuron-like differentiation and cell proliferation arrest through specific activation of the MAP kinase pathway.
Tissue Specificity Expressed in brain and CNS. Also expressed in the small intestine and testis, but not in normal lymphoid cells. {ECO:0000269|PubMed:9174053}.
Top Pathways Non-small cell lung cancer

ALK CRISPR/Cas9 KO Plasmid (h) - sc-400460 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALK HDR Plasmid (h) - sc-400460-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALK Double Nickase Plasmid (h) - sc-400460-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALK Double Nickase Plasmid (h2) - sc-400460-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALK CRISPR Activation Plasmid (h) - sc-400460-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALK CRISPR Activation Plasmid (h2) - sc-400460-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALK Lentiviral Activation Particles (h) - sc-400460-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALK Lentiviral Activation Particles (h2) - sc-400460-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ALK siRNA (h) - sc-40083 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ALK shRNA Plasmid (h) - sc-40083-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ALK shRNA (h) Lentiviral Particles - sc-40083-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN2204 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2204 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03855 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr03855

ALK siRNA (Human) - CRH0165 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALK - MBS8230247 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ALK/CD246 RNAi - H00000238-R04 from Novus Biologicals

Category siRNA
Prices $289.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human ALK (NM_004304.4) - SHH235202 from Creative biogene

Category siRNA
Species Reactivities Human

ALK shRNA Plasmid (Human) - CHH0165 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

ALK miRNA 3'UTR clone - MiUTR3H-00138 from Creative biogene

Species Reactivities Human
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