PRKACA

Gene Symbol	PRKACA
Entrez Gene	5566
Alt Symbol	PKACA, PPNAD4
Species	Human
Gene Type	protein-coding
Description	protein kinase, cAMP-dependent, catalytic, alpha
Other Description	PKA C-alpha|cAMP-dependent protein kinase catalytic subunit alpha|protein kinase A catalytic subunit
Swissprots	Q32P54 Q9NRH9 Q9H2Y0 Q9NRB4 P17612
Accessions	ABG25918 EAW84397 EAW84398 EAW84399 EAW84400 P17612 AF208004 AAG35720 AF224718 AAF75622 AF239744 AAF76426 AK093803 AK131561 AK290147 BAF82836 AK292284 BAF84973 AK301264 BAH13444 BC039846 AAH39846 BC108259 AAI08260 BU543573 M80335 AAA60094 X07767 CAA30597 NM_001304349 NP_001291278 NM_002730 NP_002721 NM_207518 NP_997401
Function	Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B- alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasi
Subcellular Location	Cytoplasm. Cell membrane. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 is ubiquitous. Isoform 2 is sperm- specific and is enriched in pachytene spermatocytes but is not detected in round spermatids. {ECO:0000269|PubMed:10906071, ECO:0000269|PubMed:21812984}.
Top Pathways	Calcium signaling pathway, Ovarian steroidogenesis, MAPK signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Mouse/Human/Rat PRKACA + PRKACB ELISA Kit (Cell-Based ELISA) - LS-F3061 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.78-50 ng/ml

Human PRKACA + PRKACB ELISA Kit (Sandwich ELISA) - LS-F11868 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.78 Range 0.78-50 ng/ml

KAPC A/B Colorimetric Cell-Based ELISA - CB5847 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

PKA alpha/beta CAT (Phospho-Thr197) Colorimetric Cell-Based ELISA Kit - CBP1201 from Assay Biotechnology Category ELISA Kit Prices $480.00, $960.00, $1,440.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

cAMP dependent protein kinase catalytic subunit Alpha (PRKACA), ELISA Kit - MBS7220198 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7249920 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7202055 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.1 ng/mL.

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7205449 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7212639 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7247204 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7208834 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7236494 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7213217 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7204770 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7228898 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

cAMP-dependent protein kinase catalytic subunit alpha (PRKACA), ELISA Kit - MBS7242735 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

protein kinase, cAMP-dependent, catalytic, alpha, ELISA Kit - MBS9330748 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0ng/ml. Range 3.12ng/ml-100ng/ml.

PKA Assay Kit - 17-134 from EMD Millipore Category Assay Kit

Pig PRKACA + PRKACB ELISA Kit (Custom ELISA) - LS-F18813 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Rat PRKACA + PRKACB ELISA Kit (Custom ELISA) - LS-F18814 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Bovine PRKACA + PRKACB ELISA Kit (Custom ELISA) - LS-F18815 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Dog PRKACA + PRKACB ELISA Kit (Custom ELISA) - LS-F18816 from LifeSpan Bioscience Category ELISA Kit Prices $700.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

Mouse PRKACA + PRKACB ELISA Kit (Custom ELISA) - LS-F18812 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity To be determined Range 0.78-50 ng/ml

ELISA Kit for Protein Kinase, cAMP Dependent Catalytic Alpha (PRKACa) - SEM062Hu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

ELISA Kit for Protein Kinase, cAMP Dependent Catalytic Alpha (PRKACa) - SEM062Hu from Uscn Life Science Inc. Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA’s were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

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