PRKACA

Gene Symbol	PRKACA
Entrez Gene	5566
Alt Symbol	PKACA, PPNAD4
Species	Human
Gene Type	protein-coding
Description	protein kinase, cAMP-dependent, catalytic, alpha
Other Description	PKA C-alpha|cAMP-dependent protein kinase catalytic subunit alpha|protein kinase A catalytic subunit
Swissprots	Q32P54 Q9NRH9 Q9H2Y0 Q9NRB4 P17612
Accessions	ABG25918 EAW84397 EAW84398 EAW84399 EAW84400 P17612 AF208004 AAG35720 AF224718 AAF75622 AF239744 AAF76426 AK093803 AK131561 AK290147 BAF82836 AK292284 BAF84973 AK301264 BAH13444 BC039846 AAH39846 BC108259 AAI08260 BU543573 M80335 AAA60094 X07767 CAA30597 NM_001304349 NP_001291278 NM_002730 NP_002721 NM_207518 NP_997401
Function	Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the regulation of platelets in response to thrombin and collagen; maintains circulating platelets in a resting state by phosphorylating proteins in numerous platelet inhibitory pathways when in complex with NF-kappa-B (NFKB1 and NFKB2) and I-kappa-B- alpha (NFKBIA), but thrombin and collagen disrupt these complexes and free active PRKACA stimulates platelets and leads to platelet aggregation by phosphorylating VASP. Prevents the antiproliferative and anti-invasi
Subcellular Location	Cytoplasm. Cell membrane. Nucleus {ECO:0000250}. Mitochondrion {ECO:0000250}. Note=Translocates into the nucleus (monomeric catalytic subunit). The inactive holoenzyme is found in the cytoplasm. Distributed throughout the cytoplasm in meiotically incompetent oocytes. Associated to mitochondrion as meiotic competence is acquired. Aggregates around the germinal vesicles (GV) at the immature GV stage oocytes (By similarity). {ECO:0000250}.
Tissue Specificity	Isoform 1 is ubiquitous. Isoform 2 is sperm- specific and is enriched in pachytene spermatocytes but is not detected in round spermatids. {ECO:0000269|PubMed:10906071, ECO:0000269|PubMed:21812984}.
Top Pathways	Calcium signaling pathway, Ovarian steroidogenesis, MAPK signaling pathway, Estrogen signaling pathway, Adrenergic signaling in cardiomyocytes

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human cAMP Protein Kinase Catalytic subunit full length protein - ab56268 from Abcam Category Protein Prices $302.00 Sizes 10 µg Source Baculovirus infected sf9 cells Species Human

Active human PRKACA full length protein - ab73791 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source E. coli Species Human

Human cAMP Protein Kinase Catalytic subunit full length protein - ab56709 from Abcam Category Protein Prices $434.00 Sizes 5 µg Source E. coli Species Human

PRKACA-Antibody-N-term-K82-Blocking-Peptide - BP6822a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PKA-C-alphaPKA-C-beta-Antibody-N-term-Blocking-peptide - BP7013a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PKA C beta (Active) recombinant protein - GTX65207 from GeneTex Category Protein Prices $329.00 Sizes 5 μg Source Baculovirus (Sf9 insect cells) Species Human

Recombinant Human Active PKA C alpha, CF - 4268-KS-010 from R&D Systems Category Protein

PRKACA Protein (OPPA01114) - OPPA01114 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 1 µg Source E. Coli

PKAca protein - 30R-2857 from Fitzgerald Category Protein Prices $250.00 Sizes 5 µg Source Sf-9 insect cells Species Human

PRKACA - H00005566-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKACA - H00005566-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKACA - H00005566-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

PRKACA - H00005566-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PRKACA - H00005566-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PRKACA - P4226 from Acris Antibodies Category Protein Prices $670.00 Sizes 5 µg Species Human

PRKACA control peptide - AP00040CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

cAMP-Dependent Protein Kinase A catalytic subunit α Recombinant - 228-11306-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli.

Recombinant PRKACA - 228-11306-2 from RayBiotech Category Protein Prices $189.00 Sizes 2 µg Source Escherichia Coli.

Recombinant PRKACA - 228-11306-3 from RayBiotech Category Protein Prices $2,250.00 Sizes 3 µg Source Escherichia Coli.

PRKACA fusion protein - ag5706 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

PRKACA fusion protein - Ag21478 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PRKACA - PKPS-207 from NeoScientific Category Protein Prices $65.00, $169.00, $2,795.00 Sizes 1 µg, 5 µg, 100 µg Source Escherichia Coli.

Recombinant cAMP-Dependent Protein Kinase A catalytic subunitA - BP000815-PKA-200 from Syd Labs Category Protein Prices $160.00, $2,150.00 Sizes 5 µg, 100 µg Source E. coli-derived.

Recombinant Human PRKACA, GST-tagged, Active - PRKACA-394H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human PRKACA - PRKACA-31113TH from Creative Biomart Category Protein Source E. coli

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