Lgr5

Gene Symbol Lgr5
Entrez Gene 14160
Alt Symbol FEX, Gpr49
Species Mouse
Gene Type protein-coding
Description leucine rich repeat containing G protein coupled receptor 5
Other Description G protein-coupled receptor 49|G-protein coupled receptor 49|follicle expressed hormone|leucine-rich repeat-containing G-protein coupled receptor 5|orphan G-protein coupled receptor FEX
Swissprots Q3V1L2 Q9Z1P4
Accessions EDL21772 EDL21773 Q9Z1P4 AF110818 AAD14684 AK047873 BAC33180 AK132387 BAE21138 AK134981 BC156649 AAI56650 BM935530 NM_010195 NP_034325
Function Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21727895}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. {ECO:0000250}.
Tissue Specificity Expressed in the gonads, the adrenal gland, and in the brain. In the central nervous system expression is restricted to the olfactory bulb. In the adrenal gland detected only in the neural-crest derived chromaffin cells of the medulla, but not in the cells of the adrenal cortex. In the gonads, the expression is high in Graafian follicle, but absent from primary and secondary follicles. In the intestine, exclusively expressed in cycling crypt base columnar cells. Expressed in the lower bulge and secondary germ area of telogen hair follicles and in the lower outer root sheath of anagen hair follicle. {ECO:0000269|PubMed:17934449, ECO:0000269|PubMed:18849992, ECO:0000269|PubMed:9920770}.

Lgr5/GPR49 Antibody (889901) - MAB82401 from Novus Biologicals

Prices $99.00, $249.00
Sizes 25 µg, 100 µg
Host Rat
Clonality Monoclonal
Clone 889901
HEK293 human embryonic kidney cell line transfected with (A) mouse Lgr5/GPR49 or (B) irrelevant transfectant and eGFP was stained with Rat Anti-Mouse Lgr5/GPR49 Monoclonal Antibody (Catalog # MAB82401) followed by Allophycocyanin-conjugated Anti-Rat IgG Secondary Antibody (Catalog # F0113). Quadrant markers were set based on control antibody staining (Catalog # MAB0061).

GPR49/LGR5 Polyclonal Antibody - bs-1117R from Bioss

Prices $279.50
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded human colon carcinoma labeled with Anti-GPR49/LGR5 Polyclonal Antibody, Unconjugated (bs-1117R) at 1:200 followed by conjugation to the secondary antibody and DAB staining.

LGR5 Antibody (OABF00479) - OABF00479 from Aviva Systems Biology

Prices $289.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

anti-LGR5 / GPR49 antibody - ARG51467 from Arigo Biolaboratories

Host Rabbit
Clonality Polyclonal
ARG51467 anti-LGR5 / GPR49 antibody WB image Western Blot: extracts from HeLa, 3T3 and HepG2 cells stained with anti-LGR5 / GPR49 antibody ARG51467.

anti-LGR5 / GPR49 antibody - ARG55261 from Arigo Biolaboratories

ARG55261 anti-LGR5 / GPR49 antibody WB image Western blot: 20 μg of 1) HeLa, 2) HepG2, 3) SH-SY5Y cell lysates stained with ARG55261 anti-LGR5 / GPR49 antibody at 1:1000 dilution.

Lgr5/GPR49 Antibody (803420) [Alexa Fluor (R) 405] - FAB8240V from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 803420

Lgr5/GPR49 Antibody (803420) [Alexa Fluor (R) 350] - FAB8240U from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 803420

Lgr5/GPR49 Antibody (803420) [Alexa Fluor (R) 594] - FAB8240T from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 803420

Lgr5/GPR49 Antibody (803420) [Alexa Fluor (R) 750] - FAB8240S from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 803420

Lgr5/GPR49 Antibody (803420) [Alexa Fluor (R) 647] - FAB8240R from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 803420

Lgr5/GPR49 Antibody (803420) [Alexa Fluor (R) 700] - FAB8240N from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 803420

Lgr5/GPR49 Antibody (803420) [Alexa Fluor (R) 488] - FAB8240G from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 803420

Lgr5/GPR49 Antibody (889901) [Alexa Fluor (R) 405] - FAB82401V from Novus Biologicals

Prices $319.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 889901

Lgr5/GPR49 Antibody (889901) [Alexa Fluor (R) 350] - FAB82401U from Novus Biologicals

Prices $319.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 889901

Lgr5/GPR49 Antibody (889901) [Alexa Fluor (R) 594] - FAB82401T from Novus Biologicals

Prices $319.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 889901

Lgr5/GPR49 Antibody (889901) [Alexa Fluor (R) 750] - FAB82401S from Novus Biologicals

Prices $319.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 889901

Lgr5/GPR49 Antibody (889901) [Alexa Fluor (R) 647] - FAB82401R from Novus Biologicals

Prices $319.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 889901

Lgr5/GPR49 Antibody (889901) [Alexa Fluor (R) 700] - FAB82401N from Novus Biologicals

Prices $319.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 889901

Lgr5/GPR49 Antibody (889901) [Alexa Fluor (R) 488] - FAB82401G from Novus Biologicals

Prices $319.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone 889901
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