| Gene Symbol |
Lgr5
|
| Entrez Gene |
14160
|
| Alt Symbol |
FEX, Gpr49
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing G protein coupled receptor 5
|
| Other Description |
G protein-coupled receptor 49|G-protein coupled receptor 49|follicle expressed hormone|leucine-rich repeat-containing G-protein coupled receptor 5|orphan G-protein coupled receptor FEX
|
| Swissprots |
Q3V1L2 Q9Z1P4
|
| Accessions |
EDL21772 EDL21773 Q9Z1P4 AF110818 AAD14684 AK047873 BAC33180 AK132387 BAE21138 AK134981 BC156649 AAI56650 BM935530 NM_010195 NP_034325
|
| Function |
Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21727895}.
|
| Subcellular Location |
Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in the gonads, the adrenal gland, and in the brain. In the central nervous system expression is restricted to the olfactory bulb. In the adrenal gland detected only in the neural-crest derived chromaffin cells of the medulla, but not in the cells of the adrenal cortex. In the gonads, the expression is high in Graafian follicle, but absent from primary and secondary follicles. In the intestine, exclusively expressed in cycling crypt base columnar cells. Expressed in the lower bulge and secondary germ area of telogen hair follicles and in the lower outer root sheath of anagen hair follicle. {ECO:0000269|PubMed:17934449, ECO:0000269|PubMed:18849992, ECO:0000269|PubMed:9920770}.
|