Lgr5

Gene Symbol Lgr5
Entrez Gene 14160
Alt Symbol FEX, Gpr49
Species Mouse
Gene Type protein-coding
Description leucine rich repeat containing G protein coupled receptor 5
Other Description G protein-coupled receptor 49|G-protein coupled receptor 49|follicle expressed hormone|leucine-rich repeat-containing G-protein coupled receptor 5|orphan G-protein coupled receptor FEX
Swissprots Q3V1L2 Q9Z1P4
Accessions EDL21772 EDL21773 Q9Z1P4 AF110818 AAD14684 AK047873 BAC33180 AK132387 BAE21138 AK134981 BC156649 AAI56650 BM935530 NM_010195 NP_034325
Function Receptor for R-spondins that potentiates the canonical Wnt signaling pathway and acts as a stem cell marker of the intestinal epithelium and the hair follicle. Upon binding to R- spondins (RSPO1, RSPO2, RSPO3 or RSPO4), associates with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. In contrast to classical G-protein coupled receptors, does not activate heterotrimeric G-proteins to transduce the signal. Involved in the development and/or maintenance of the adult intestinal stem cells during postembryonic development. {ECO:0000269|PubMed:21727895}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Golgi apparatus, trans-Golgi network membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Rapidly and constitutively internalized to the trans-Golgi network at steady state. {ECO:0000250}.
Tissue Specificity Expressed in the gonads, the adrenal gland, and in the brain. In the central nervous system expression is restricted to the olfactory bulb. In the adrenal gland detected only in the neural-crest derived chromaffin cells of the medulla, but not in the cells of the adrenal cortex. In the gonads, the expression is high in Graafian follicle, but absent from primary and secondary follicles. In the intestine, exclusively expressed in cycling crypt base columnar cells. Expressed in the lower bulge and secondary germ area of telogen hair follicles and in the lower outer root sheath of anagen hair follicle. {ECO:0000269|PubMed:17934449, ECO:0000269|PubMed:18849992, ECO:0000269|PubMed:9920770}.

Leucine-rich repeat-containing G-protein coupled receptor 5 (LGR5), Mouse, ELISA Kit - CSB-EL012906MO from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

leucine-rich repeat-containing G protein-coupled receptor 5, ELISA Kit - MBS944512 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity The minimum detectable dose of mouse LGR5 is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mean O.D value of 20 replicates of the zero standard added by their three standard deviations.
Range 31.25 pg/ml -2000 pg/ml.

Mouse Leucine-rich repeat-containing G-protein coupled receptor 5(LGR5) ELISA ki - CSB-EL012906MO from Cusabio

Sensitivity 7.81 pg/ml
Range 31.25 pg/ml-2000 pg/ml

Mouse Lgr5 ELISA Kit - E058592 from Biobool

Category ELISA Kit
Sensitivity The minimum detectable dose of mouse LGR5 is typically less than 7.81 pg/ml. The sensitivity of this assay, or Lower Limit of Detection (LLD) was defined as the lowest protein concentration that could be differentiated from zero. It was determined the mea

LGR5 ELISA Kit (Mouse) (OKCA01707) - OKCA01707 from Aviva Systems Biology

Category ELISA Kit
Prices $600.00
Sizes 96 wells
Sensitivity 7.81 pg/mL
Range 31.25 - 2,000 pg/mL

LGR-5 (leucine-rich repeat-containing g-protein coupled receptor 5), ELISA Kit - MBS7606815 from MyBioSource

Category ELISA Kit
Prices $295.00, $390.00, $1,615.00, $3,015.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 9.375pg/ml
Range 15.6-1000pg/ml
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