RASGRF2

Gene Symbol	RASGRF2
Entrez Gene	5924
Alt Symbol	GRF2, RAS-GRF2
Species	Human
Gene Type	protein-coding
Description	Ras protein-specific guanine nucleotide-releasing factor 2
Other Description	ras guanine nucleotide exchange factor 2\|ras-specific guanine nucleotide-releasing factor 2
Swissprots	B9EG89 Q9UK56 O14827
Accessions	CAH05619 EAW95863 O14827 AF023130 AAB80953 AF181250 AAD55268 AK094809 AL598102 BC041953 BC126112 AAI26113 BC136296 AAI36297 BC143870 BU430075 BX502901 CR749239 CAH18095 DA219722 DA230428 XM_005248565 XP_005248622 NM_006909 NP_008840
Function	Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269\|PubMed:15128856}.
Subcellular Location	Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.
Tissue Specificity	Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level). {ECO:0000269\|PubMed:10373510, ECO:0000269\|PubMed:11856323}.
Top Pathways	MAPK signaling pathway

Ras-GRF2 (C-20) - sc-7591 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Ras-GRF2 (C-20): sc-7591. Western blot analysis of Ras-GRF2 expression in mouse brain extract.

Anti-RASGRF2 antibody - ab121577 from Abcam

Prices	$443.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ab121577, at a 1/150 dilution, staining RASGRF2 in paraffin-embedded Human colon tissue by immunohistochemistry.

RASGRF2 Antibody - NBP1-83331 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: RASGRF2 Antibody [NBP1-83331] - Analysis in human cell line CACO-2.

RASGRF2 Antibody - 38230002 from Novus Biologicals

Prices	$299.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

RASGRF2 Antibody - NBP2-20088 from Novus Biologicals

Prices	$349.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: RASGRF2 Antibody [NBP2-20088] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 5% SDS PAGE gel, diluted at 1:1000.

RASGRF2 Antibody - NBP2-20087 from Novus Biologicals

Prices	$329.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: RASGRF2 Antibody [NBP2-20087] - Sample (50 ug of whole cell lysate) A: Mouse Brain, 5% SDS PAGE gel, diluted at 1:1000.

GRF2 Polyclonal Antibody - bs-16311R from Bioss

Prices	$269.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Mouse placenta lysate probed with Rabbit Anti-GRF2 Polyclonal Antibody, Unconjugated (bs-16311R) at 1:300 in 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:5000 for 90min at 37˚C.

Anti-RASGRF2 antibody produced in rabbit - SAB2700396 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-RASGRF2: <B>Cat. No. SAB2700396</B>: Western Blot analysis of RASGRF2 in extracts from <B>Lanes</B><BR/>A. Mouse brain using <B>Cat. No. SAB2700396</B> at a 1:1000 dilution.

Anti-RASGRF2 (C-terminal) antibody produced in rabbit - SAB2700401 from Sigma-Aldrich

Prices	$326.50
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunoblotting</B><BR/>Anti-RASGRF2 (C-terminal): <B>Cat. No. SAB2700401</B>: Western Blot analysis of RASGRF2 in extracts from <B>Lanes</B><BR/>A. Mouse brain using <B>Cat. No. SAB2700401</B> at a 1:1000 dilution.

Anti-RASGRF2 antibody produced in rabbit - HPA018679 from Sigma-Aldrich

Prices	$429.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

<B>Immunohistochemistry</B><BR/>Anti-RASGRF2: <B>Cat. No. HPA018679</B>: Immunohistochemical staining of human colon shows strong cytoplasmic positivity in glandular cells.

RASGRF2-Specific antibody - 19717-1-AP from Proteintech Group

Host	Rabbit
Clonality	Polyclonal

Anti-RASGRF2 (aa 702-807) polyclonal antibody - DPABH-18931 from Creative Diagnostics

Host	Rabbit
Clonality	Polyclonal

Ras GRF2 - MBS274514 from MyBioSource

Prices	$360.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Sample (50 ug of whole cell lysate) A: mouse brain 5% SDS PAGE diluted at 1:1000

Ras GRF2 - MBS275794 from MyBioSource

Prices	$360.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

RASGRF2, Polyclonal Antibody - MBS540773 from MyBioSource

Prices	$390.00
Sizes	0.1 mg affinity-purified
Host	Rabbit
Clonality	Polyclonal

RASGRF2 Antibody - RASGRF2-201AP from FabGennix

Prices	$265.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

GRF2 Polyclonal Antibody , Biotin Conjugated - bs-16311R-Biotin from Bioss

Prices	$349.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

GRF2 Polyclonal Antibody , HRP Conjugated - bs-16311R-HRP from Bioss

Prices	$369.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

RASGRF2 antibody - TA590561 from Acris Antibodies

Prices	$325.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

RASGRF2 Antibody - abx122313 from Abbexa

Host	Rabbit
Clonality	Polyclonal

RASGRF2 antibody - orb258360 from Biorbyt

Prices	$425.00
Sizes	100 μg
Host	Rabbit
Clonality	Polyclonal

Anti-GRF2 Antibody A06617 - A06617 from Boster Bio

Prices	$245.00
Sizes	1
Host	Rabbit
Clonality	Polyclonal

RASGRF2, Polyclonal Antibody - MBS544685 from MyBioSource

Prices	$495.00
Sizes	0.1 mg biotin
Host	Rabbit
Clonality	Polyclonal

RASGRF2, Polyclonal Antibody - MBS544686 from MyBioSource

Prices	$495.00
Sizes	0.1 mg fitc
Host	Rabbit
Clonality	Polyclonal

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