RASGRF2

Gene Symbol RASGRF2
Entrez Gene 5924
Alt Symbol GRF2, RAS-GRF2
Species Human
Gene Type protein-coding
Description Ras protein-specific guanine nucleotide-releasing factor 2
Other Description ras guanine nucleotide exchange factor 2|ras-specific guanine nucleotide-releasing factor 2
Swissprots B9EG89 Q9UK56 O14827
Accessions CAH05619 EAW95863 O14827 AF023130 AAB80953 AF181250 AAD55268 AK094809 AL598102 BC041953 BC126112 AAI26113 BC136296 AAI36297 BC143870 BU430075 BX502901 CR749239 CAH18095 DA219722 DA230428 XM_005248565 XP_005248622 NM_006909 NP_008840
Function Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}.
Subcellular Location Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.
Tissue Specificity Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level). {ECO:0000269|PubMed:10373510, ECO:0000269|PubMed:11856323}.
Top Pathways MAPK signaling pathway

Ras-GRF2 CRISPR/Cas9 KO Plasmid (h) - sc-404141 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ras-GRF2 HDR Plasmid (h) - sc-404141-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ras-GRF2 Double Nickase Plasmid (h) - sc-404141-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ras-GRF2 Double Nickase Plasmid (h2) - sc-404141-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ras-GRF2 CRISPR Activation Plasmid (h) - sc-404141-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ras-GRF2 CRISPR Activation Plasmid (h2) - sc-404141-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ras-GRF2 Lentiviral Activation Particles (h) - sc-404141-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ras-GRF2 Lentiviral Activation Particles (h2) - sc-404141-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ras-GRF2 siRNA (h) - sc-36395 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ras-GRF2 shRNA Plasmid (h) - sc-36395-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ras-GRF2 shRNA (h) Lentiviral Particles - sc-36395-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU009231 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN17983 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17983 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RASGRF2 siRNA (Human) - CRH4010 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RASGRF2 - MBS8207491 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RASGRF2 (NM_006909.2) - SHH390012 from Creative biogene

Category siRNA
Species Reactivities Human

Human RASGRF2 siRNA - orb264512 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RASGRF2 shRNA Plasmid (Human) - CHH4010 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RASGRF2 miRNA 3'UTR clone - MiUTR3H-08609 from Creative biogene

Species Reactivities Human
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