| Gene Symbol |
RASGRF2
|
| Entrez Gene |
5924
|
| Alt Symbol |
GRF2, RAS-GRF2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Ras protein-specific guanine nucleotide-releasing factor 2
|
| Other Description |
ras guanine nucleotide exchange factor 2|ras-specific guanine nucleotide-releasing factor 2
|
| Swissprots |
B9EG89 Q9UK56 O14827
|
| Accessions |
CAH05619 EAW95863 O14827 AF023130 AAB80953 AF181250 AAD55268 AK094809 AL598102 BC041953 BC126112 AAI26113 BC136296 AAI36297 BC143870 BU430075 BX502901 CR749239 CAH18095 DA219722 DA230428 XM_005248565 XP_005248622 NM_006909 NP_008840
|
| Function |
Functions as a calcium-regulated nucleotide exchange factor activating both Ras and RAC1 through the exchange of bound GDP for GTP. Preferentially activates HRAS in vivo compared to RRAS based on their different types of prenylation. Functions in synaptic plasticity by contributing to the induction of long term potentiation. {ECO:0000269|PubMed:15128856}.
|
| Subcellular Location |
Cytoplasm. Cell membrane; Peripheral membrane protein. Endoplasmic reticulum membrane; Peripheral membrane protein. Note=Translocates to membranes when activated. Found both at cell periphery and along the axon of neurons (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Widely expressed with higher expression in brain, followed by heart, lung, pancreas and kidney. Detected in placenta. Expressed in brain and lung (at protein level). {ECO:0000269|PubMed:10373510, ECO:0000269|PubMed:11856323}.
|
| Top Pathways |
MAPK signaling pathway
|