A1CF

Gene Symbol A1CF
Entrez Gene 29974
Alt Symbol ACF, ACF64, ACF65, APOBEC1CF, ASP
Species Human
Gene Type protein-coding
Description APOBEC1 complementation factor
Other Description APOBEC-1 stimulating protein|apo-B RNA editing protein|apobec-1 complementation factor (ACF) (ASP)
Swissprots Q9NZD3 A8K7G7 A1L4F2 Q9NXC9 Q5SZQ0 Q9NQ93 Q9NQ94 Q9NQX8 Q9NQX9 B7ZM14
Accessions EAW54133 EAW54134 EAW54135 EAW54136 EAW54137 EAW54138 Q9NQ94 AF209192 AAF34824 AF271789 AAF76221 AF271790 AAF76222 AJ272078 CAB94754 AJ272079 CAB94755 AK000324 BAA91086 AK130022 AK291982 BAF84671 AK303801 BAG64755 BC022263 BC054873 AAH54873 BC130519 AAI30520 BC144194 BC144196 AAI44197 BG188383 CR749831 XM_005269718 XP_005269775 XM_005269720 XP_005269777 XM_011539729 XP_011538031 XM_011539730 XP_011538032 NM_001198818 NP_001185747 NM_001198819 NP_001185748 NM_001198820 NP_001185749 NM_014576 NP_055391 NM_138932 NP_620310 NM_138933 NP_620311
Function Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591, ECO:0000269|PubMed:12881431}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12881431}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269|PubMed:10669759}.

ACF 293T Cell Transient Overexpression Lysate(Denatured) - H00029974-T01 from Acris Antibodies

Category Cell Lysate
Prices $320.00
Sizes 100 µl

A1CF 293 Cell Lysate - 404649 from ABBIOTEC

Category Cell Lysate
Prices $672.00
Sizes 100 µg

A1CF Over-expression Lysate Product - GWB-A069C4 from Genway Biotech

Category Cell Lysate
Prices $756.00
Sizes 100 µg
Species Human

ACF Overexpression Lysate (Denatured) - H00029974-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

ACF Overexpression Lysate (Denatured) - H00029974-T02 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl
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