A1CF

Gene Symbol A1CF
Entrez Gene 29974
Alt Symbol ACF, ACF64, ACF65, APOBEC1CF, ASP
Species Human
Gene Type protein-coding
Description APOBEC1 complementation factor
Other Description APOBEC-1 stimulating protein|apo-B RNA editing protein|apobec-1 complementation factor (ACF) (ASP)
Swissprots Q9NZD3 A8K7G7 A1L4F2 Q9NXC9 Q5SZQ0 Q9NQ93 Q9NQ94 Q9NQX8 Q9NQX9 B7ZM14
Accessions EAW54133 EAW54134 EAW54135 EAW54136 EAW54137 EAW54138 Q9NQ94 AF209192 AAF34824 AF271789 AAF76221 AF271790 AAF76222 AJ272078 CAB94754 AJ272079 CAB94755 AK000324 BAA91086 AK130022 AK291982 BAF84671 AK303801 BAG64755 BC022263 BC054873 AAH54873 BC130519 AAI30520 BC144194 BC144196 AAI44197 BG188383 CR749831 XM_005269718 XP_005269775 XM_005269720 XP_005269777 XM_011539729 XP_011538031 XM_011539730 XP_011538032 NM_001198818 NP_001185747 NM_001198819 NP_001185748 NM_001198820 NP_001185749 NM_014576 NP_055391 NM_138932 NP_620310 NM_138933 NP_620311
Function Essential component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in APOB mRNA. Binds to APOB mRNA and is probably responsible for docking the catalytic subunit, APOBEC1, to the mRNA to allow it to deaminate its target cytosine. The complex also protects the edited APOB mRNA from nonsense-mediated decay. {ECO:0000269|PubMed:10669759, ECO:0000269|PubMed:10781591, ECO:0000269|PubMed:12881431}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12881431}. Endoplasmic reticulum {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:12881431}. Note=Predominantly nuclear where it localizes to heterochromatin. Also cytoplasmic where it is found at the outer surface of the endoplasmic reticulum (By similarity). Shuttles between the nucleus and cytoplasm. May be transported into the nucleus by the nuclear import protein TNPO2/TRN2 or by APOBEC1. {ECO:0000250}.
Tissue Specificity Widely expressed with highest levels in brain, liver, pancreas, colon and spleen. {ECO:0000269|PubMed:10669759}.

ACF (E-15) - sc-163621 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ACF (Y-13) - sc-163623 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-A1CF antibody - ab99955 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-A1CF antibody (ab99955) at 1/1000 dilutionLane 1 : human fetal liver lysateLane 2 : human fetal heart lysate

Anti-A1CF antibody - ab89050 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Anti-A1CF antibody (ab89050) at 1 µg/ml + Human placenta lysate at 50 µg

Anti-A1CF antibody - ab94598 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-A1CF antibody (ab94598) at 1 µg/ml (in 5% skim milk / PBS buffer) + Human fetal spleen lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-A1CF antibody - ab83276 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-A1CF antibody (ab83276) at 1 µg/ml + HepG2 cell lysate at 10 µgSecondaryHRP conjugated anti-Rabbit IgG at 1/50000 dilution

Anti-A1CF antibody - C-terminal - ab187002 from Abcam

Host Rabbit
Clonality Polyclonal
All lanes : Anti-A1CF antibody - C-terminal (ab187002) at 1/1000 dilutionLane 1 : Mouse thymus total cell extractLane 2 : Jurkat total cell extract

Anti-A1CF / ACF Antibody (aa394-423, AP) - LS-C232367 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-A1CF / ACF Antibody (aa394-423, Biotin) - LS-C232368 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-A1CF / ACF Antibody (aa394-423, APC) - LS-C232369 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-A1CF / ACF Antibody (aa394-423, FITC) - LS-C232370 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-A1CF / ACF Antibody (aa394-423, PE) - LS-C232371 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-A1CF / ACF Antibody (aa394-423, Azide-free, HRP) - LS-C249365 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-A1CF / ACF Antibody - LS-C306005 from LifeSpan Bioscience

Prices $455.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal

Anti-A1CF / ACF Antibody (aa397-427) - LS-C319280 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-A1CF / ACF Antibody (N-Terminus) - LS-C101888 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A1CF antibody LS-C101888 Western blot of HepG2 cell lysate.

Anti-A1CF / ACF Antibody (N-Terminus) - LS-C110566 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A1CF antibody LS-C110566 Western blot of Fetal Spleen lysate.

Anti-A1CF / ACF Antibody (aa389-587) - LS-C314503 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of recombinant A1CF / ACF.

Anti-A1CF / ACF Antibody (aa6-55) - LS-C205714 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
A1CF / ACF antibody Western Blot of Liver Tumor. Antibody dilution: 1 ug/ml.

Anti-A1CF / ACF Antibody (aa394-423) - LS-C155929 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ACF Antibody immunohistochemistry of formalin-fixed and paraffin-embedded human hepatocarcinoma followed by peroxidase-conjugated secondary antibody and DAB staining.

Anti-A1CF / ACF Antibody IHC-plus™ - LS-B9393 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-A1CF / ACF antibody IHC staining of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

ACF Antibody - NBP2-33412 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: ACF Antibody [NBP2-33412] - Immunofluorescent staining of human cell line CACO-2 shows localization to nucleoplasm.

ACF Antibody - H00029974-B01 from Novus Biologicals

Prices $349.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
Western Blot: ACF Antibody [H00029974-B01] - Western Blot analysis of ACF expression in human placenta.

ACF Antibody - H00029974-B01P from Novus Biologicals

Prices $359.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
Western Blot: ACF Antibody [H00029974-B01P] - Analysis of ACF expression in human placenta.

ACF Antibody - NBP1-57308 from Novus Biologicals

Prices $139.00, $329.00
Sizes 20 µl, 100 µl
Host Rabbit
Clonality Polyclonal
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