| Gene Symbol |
Tln1
|
| Entrez Gene |
21894
|
| Alt Symbol |
Tln
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
talin 1
|
| Other Description |
talin-1
|
| Swissprots |
P26039 Q8VEF0 A2AIM8
|
| Accessions |
EDL02465 EDL02466 EDL02467 P26039 AK006088 AK040128 BAC30516 AK122420 BAC65702 AK147228 BAE27781 AK170630 BAE41923 AK171322 BAE42391 AK190044 BC018557 AAH18557 BC050080 BC055348 BC059711 BC121787 AAI21788 BC150810 AAI50811 CJ242702 X56123 CAA39588 XM_006537768 XP_006537831 XM_006537769 XP_006537832 XM_006537770 XP_006537833 XM_006537771 XP_006537834 NM_011602 NP_035732
|
| Function |
Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.
|
| Subcellular Location |
Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000269|PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269|PubMed:21768292}. Note=Colocalizes with LAYN at the membrane ruffles (By similarity). Localized preferentially in focal adhesions than fibrillar adhesions. {ECO:0000250}.
|
| Top Pathways |
Focal adhesion, HTLV-I infection, Rap1 signaling pathway
|