Gene Symbol | Tln1 |
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Entrez Gene | 21894 |
Alt Symbol | Tln |
Species | Mouse |
Gene Type | protein-coding |
Description | talin 1 |
Other Description | talin-1 |
Swissprots | P26039 Q8VEF0 A2AIM8 |
Accessions | EDL02465 EDL02466 EDL02467 P26039 AK006088 AK040128 BAC30516 AK122420 BAC65702 AK147228 BAE27781 AK170630 BAE41923 AK171322 BAE42391 AK190044 BC018557 AAH18557 BC050080 BC055348 BC059711 BC121787 AAI21788 BC150810 AAI50811 CJ242702 X56123 CAA39588 XM_006537768 XP_006537831 XM_006537769 XP_006537832 XM_006537770 XP_006537833 XM_006537771 XP_006537834 NM_011602 NP_035732 |
Function | Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts. |
Subcellular Location | Cell projection, ruffle membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Cell surface {ECO:0000269|PubMed:21768292}. Cell junction, focal adhesion {ECO:0000269|PubMed:21768292}. Note=Colocalizes with LAYN at the membrane ruffles (By similarity). Localized preferentially in focal adhesions than fibrillar adhesions. {ECO:0000250}. |
Top Pathways | Focal adhesion, HTLV-I infection, Rap1 signaling pathway |
Talin-1 CRISPR/Cas9 KO Plasmid (m) - sc-423417 from Santa Cruz Biotechnology
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Talin-1 HDR Plasmid (m) - sc-423417-HDR from Santa Cruz Biotechnology
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Talin-1 Double Nickase Plasmid (m) - sc-423417-NIC from Santa Cruz Biotechnology
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Talin-1 Double Nickase Plasmid (m2) - sc-423417-NIC-2 from Santa Cruz Biotechnology
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Talin CRISPR Activation Plasmid (m) - sc-423417-ACT from Santa Cruz Biotechnology
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Talin-1 CRISPR Activation Plasmid (m2) - sc-423417-ACT-2 from Santa Cruz Biotechnology
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Talin-1 Lentiviral Activation Particles (m) - sc-423417-LAC from Santa Cruz Biotechnology
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Talin-1 Lentiviral Activation Particles (m2) - sc-423417-LAC-2 from Santa Cruz Biotechnology
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Talin-1 siRNA (m) - sc-36611 from Santa Cruz Biotechnology
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Talin-1 shRNA Plasmid (m) - sc-36611-SH from Santa Cruz Biotechnology
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Talin-1 shRNA (m) Lentiviral Particles - sc-36611-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU083531 from Sigma-Aldrich
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MISSION® Long Non-Coding esiRNA - EMNC006581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN42889 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND42889 from Sigma-Aldrich
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TLN1 siRNA (Mouse) - CRM4160 from Cohesion Biosciences
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TLN1 - MBS8216760 from MyBioSource
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shRNA set against Mouse TLN1 (NM_011602.5) - SHH427900 from Creative biogene
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Talin-1 CRISPR/Cas9 KO Plasmid (m2) - sc-423417-KO-2 from Santa Cruz Biotechnology
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Talin-1 HDR Plasmid (m2) - sc-423417-HDR-2 from Santa Cruz Biotechnology
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Mouse TLN1 siRNA - orb283636 from Biorbyt
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TLN1 shRNA Plasmid (Mouse) - CHM4160 from Cohesion Biosciences
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