ZNRF1

Gene Symbol	ZNRF1
Entrez Gene	84937
Alt Symbol	NIN283
Species	Human
Gene Type	protein-coding
Description	zinc and ring finger 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase ZNRF1|nerve injury gene 283|nerve injury-induced gene 283 protein|zinc and ring finger protein 1|zinc/RING finger protein 1
Swissprots	Q9H083 Q8ND25 D3DUJ9
Accessions	CAF06461 CBJ21214 EAW95668 EAW95669 EAW95670 EAW95671 Q8ND25 AF378524 AAK69753 AK027752 AK094870 AK128349 AK294434 BAG57678 AL136903 CAB66837 AL390144 AL834440 CAD39100 AM392788 CAL37666 BC007235 AAH07235 BQ884230 EU446548 ABZ92077 XM_011523389 XP_011521691 XM_011523390 XP_011521692 XM_011523391 XP_011521693 XM_011523392 XP_011521694 XM_011523393 XP_011521695 XM_011523394 XP_011521696 XM_011523395 XP_011521697 NM_032268 NP_115644
Function	E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). {ECO:0000305|PubMed:14561866}.
Subcellular Location	Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with synaptic vesicle membranes in neurons.
Tissue Specificity	Expressed primarily in the nervous system, with expression higher in developing brain relative to adult. Expressed at low levels in testis and thymus. {ECO:0000269|PubMed:11427537, ECO:0000269|PubMed:14561866}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ZNRF1 (S-20) - sc-82464 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-ZNRF1 antibody - ab129907 from Abcam Prices $370.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 antibody - ab57938 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal

Anti-ZNRF1 Antibody (aa59-86, APC) - LS-C243559 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (aa59-86, AP) - LS-C243560 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (aa59-86, Biotin) - LS-C243561 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (aa59-86, FITC) - LS-C243562 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (aa59-86, Azide-free, HRP) - LS-C247415 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (aa59-86, PE) - LS-C243564 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (aa58-86) - LS-C326737 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (N-Terminus) - LS-C110427 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (aa59-86) - LS-C160966 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 Antibody (clone 1H4) - LS-C134112 from LifeSpan Bioscience Prices $355.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1H4

Anti-ZNRF1 Antibody (aa93-106) - LS-C186637 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

ZNRF1 Antibody - NBP1-80377 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

ZNRF1 Antibody - NBP1-84196 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

ZNRF1 Antibody (1H4) - H00084937-M01 from Novus Biologicals Prices $359.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1H4

ZNRF1 Antibody - H00084937-B01 from Novus Biologicals Prices $349.00 Sizes 50 µl Host Mouse Clonality Polyclonal

ZNRF1 Antibody - H00084937-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

ZNRF1 Antibody - H00084937-A01 from Novus Biologicals Prices $269.00 Sizes 50 µl Host Mouse Clonality Polyclonal

ZNRF1 Polyclonal Antibody - bs-9139R from Bioss Prices $269.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 antibody produced in rabbit - HPA027470 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1, (N-terminal) antibody produced in rabbit - SAB2104526 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-ZNRF1 antibody produced in mouse - SAB1408137 from Sigma-Aldrich Prices $347.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Monoclonal Anti-ZNRF1 antibody produced in mouse - WH0084937M1 from Sigma-Aldrich Prices $347.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone 1H4

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