ZNRF1

Gene Symbol ZNRF1
Entrez Gene 84937
Alt Symbol NIN283
Species Human
Gene Type protein-coding
Description zinc and ring finger 1, E3 ubiquitin protein ligase
Other Description E3 ubiquitin-protein ligase ZNRF1|nerve injury gene 283|nerve injury-induced gene 283 protein|zinc and ring finger protein 1|zinc/RING finger protein 1
Swissprots Q9H083 Q8ND25 D3DUJ9
Accessions CAF06461 CBJ21214 EAW95668 EAW95669 EAW95670 EAW95671 Q8ND25 AF378524 AAK69753 AK027752 AK094870 AK128349 AK294434 BAG57678 AL136903 CAB66837 AL390144 AL834440 CAD39100 AM392788 CAL37666 BC007235 AAH07235 BQ884230 EU446548 ABZ92077 XM_011523389 XP_011521691 XM_011523390 XP_011521692 XM_011523391 XP_011521693 XM_011523392 XP_011521694 XM_011523393 XP_011521695 XM_011523394 XP_011521696 XM_011523395 XP_011521697 NM_032268 NP_115644
Function E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). {ECO:0000305|PubMed:14561866}.
Subcellular Location Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with synaptic vesicle membranes in neurons.
Tissue Specificity Expressed primarily in the nervous system, with expression higher in developing brain relative to adult. Expressed at low levels in testis and thymus. {ECO:0000269|PubMed:11427537, ECO:0000269|PubMed:14561866}.

ZNRF1 CRISPR/Cas9 KO Plasmid (h) - sc-408060 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZNRF1 HDR Plasmid (h) - sc-408060-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZNRF1 Double Nickase Plasmid (h) - sc-408060-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZNRF1 Double Nickase Plasmid (h2) - sc-408060-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZNRF1 CRISPR Activation Plasmid (h) - sc-408060-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZNRF1 CRISPR Activation Plasmid (h2) - sc-408060-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZNRF1 Lentiviral Activation Particles (h) - sc-408060-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZNRF1 Lentiviral Activation Particles (h2) - sc-408060-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

ZNRF1 siRNA (h) - sc-77012 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZNRF1 shRNA Plasmid (h) - sc-77012-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZNRF1 shRNA (h) Lentiviral Particles - sc-77012-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

ZNRF1 RNAi - H00084937-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU066091 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN23783 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23783 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR13943 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr13943

ZNRF1 siRNA (Human) - CRJ3708 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

ZNRF1 - MBS8224801 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human ZNRF1 (NM_032268.4) - SHH455680 from Creative biogene

Category siRNA
Species Reactivities Human

ZNRF1 shRNA Plasmid (Human) - CHJ3708 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human
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