ZNRF1

Gene Symbol	ZNRF1
Entrez Gene	84937
Alt Symbol	NIN283
Species	Human
Gene Type	protein-coding
Description	zinc and ring finger 1, E3 ubiquitin protein ligase
Other Description	E3 ubiquitin-protein ligase ZNRF1|nerve injury gene 283|nerve injury-induced gene 283 protein|zinc and ring finger protein 1|zinc/RING finger protein 1
Swissprots	Q9H083 Q8ND25 D3DUJ9
Accessions	CAF06461 CBJ21214 EAW95668 EAW95669 EAW95670 EAW95671 Q8ND25 AF378524 AAK69753 AK027752 AK094870 AK128349 AK294434 BAG57678 AL136903 CAB66837 AL390144 AL834440 CAD39100 AM392788 CAL37666 BC007235 AAH07235 BQ884230 EU446548 ABZ92077 XM_011523389 XP_011521691 XM_011523390 XP_011521692 XM_011523391 XP_011521693 XM_011523392 XP_011521694 XM_011523393 XP_011521695 XM_011523394 XP_011521696 XM_011523395 XP_011521697 NM_032268 NP_115644
Function	E3 ubiquitin-protein ligase that mediates the ubiquitination of AKT1 and GLUL, thereby playing a role in neuron cells differentiation. Plays a role in the establishment and maintenance of neuronal transmission and plasticity. Regulates Schwann cells differentiation by mediating ubiquitination of GLUL. Promotes neurodegeneration by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of AKT1 in axons: degradation of AKT1 prevents AKT1-mediated phosphorylation of GSK3B, leading to GSK3B activation and phosphorylation of DPYSL2/CRMP2 followed by destabilization of microtubule assembly in axons (Probable). {ECO:0000305|PubMed:14561866}.
Subcellular Location	Endosome. Lysosome. Membrane; Peripheral membrane protein. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane {ECO:0000305}; Peripheral membrane protein {ECO:0000305}. Note=Associated with synaptic vesicle membranes in neurons.
Tissue Specificity	Expressed primarily in the nervous system, with expression higher in developing brain relative to adult. Expressed at low levels in testis and thymus. {ECO:0000269|PubMed:11427537, ECO:0000269|PubMed:14561866}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human ZNRF1 full length protein - ab164700 from Abcam Category Protein Source Wheat germ Species Human

Human ZNRF1 protein fragment - ab164701 from Abcam Category Protein Source Wheat germ Species Human

ZNRF1 Antibody Blocking Peptide - LS-E4442 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZNRF1 Antibody Blocking Peptide - LS-E14388 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ZNRF1 Antibody Blocking Peptide - LS-E27926 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ZNRF1 Protein - H00084937-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human ZNRF1 Protein - H00084937-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ZNRF1-Antibody-Center-Blocking-Peptide - BP16755c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Human E3 ubiquitin-protein ligase ZNRF1 protein - orb180463 from Biorbyt Category Protein Prices $408.00, $595.00, $2,074.00, $2,933.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Source E.coli Species Human

ZNRF1 Blocking Peptide - 33R-6033 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

ZNRF1 Peptide - AC21-2894-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

ZNRF1 - H00084937-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

ZNRF1 - H00084937-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

ZNRF1 - H00084937-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

ZNRF1 - H00084937-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ZNRF1 fusion protein - Ag15056 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human ZNRF1, His-tagged - ZNRF1-3880H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human ZNRF1, GST-tagged - ZNRF1-134H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human E3 ubiquitin-protein ligase ZNRF1(ZNRF1) - CSB-YP839856HU CSB-EP839856HU CSB-BP839856HU CSB-MP839856HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ZNRF1 Recombinant Protein Antigen - NBP1-84196PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ZNRF1 Peptide, Human - M34GP18366H from Creative Peptides Category Peptide Source Synthetic. Species Human

ZNRF1 Recombinant Protein - 92-189 from ProSci Category Protein Prices $575.00 Sizes 50 µg Source E. coli Species Human

E3 ubiquitin-protein ligase ZNRF1 (ZNRF1), Recombinant Protein - MBS1429424 from MyBioSource Category Protein Prices $980.00, $980.00, $1,200.00, $1,200.00, $1,475.00, $1,475.00, $1,940.00, $1,940.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human ZNRF1 Protein, His-tagged - ZNRF1-443H from Creative Biomart Category Protein Source E. coli Species Human

Search more