| Gene Symbol |
BEX2
|
| Entrez Gene |
84707
|
| Alt Symbol |
BEX1, DJ79P11.1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
brain expressed X-linked 2
|
| Other Description |
brain-expressed X-linked protein 2|hBex2|protein BEX2
|
| Swissprots |
Q5JVV9 B2R574 D3DXA2 F5H7H5 Q9BXY8
|
| Accessions |
CAD24039 EAW54715 EAW54716 Q9BXY8 AF251053 AAK34943 AK312085 BAG35021 AY833560 AAX40678 BC015522 AAH15522 BC050651 BI670202 BU569325 BU596902 CB961647 CD365521 CK001963 DB498563 NM_001168399 NP_001161871 NM_001168400 NP_001161872 NM_001168401 NP_001161873 NM_032621 NP_116010
|
| Function |
Regulator of mitochondrial apoptosis and G1 cell cycle in breast cancer. Protects the breast cancer cells against mitochondrial apoptosis and this effect is mediated through the modulation of BCL2 protein family, which involves the positive regulation of anti-apoptotic member BCL2 and the negative regulation of pro-apoptotic members BAD, BAK1 and PUMA. Required for the normal cell cycle progression during G1 in breast cancer cells through the regulation of CCND1 and CDKN1A. Regulates the level of PP2A regulatory subunit B and PP2A phosphatase activity. {ECO:0000269|PubMed:19711341}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000269|PubMed:16314316}.
|
| Tissue Specificity |
Expressed in central nervous system, with high level in pituitary, cerebellum and temporal lobe. Widely expressed in breast cancer cell lines. {ECO:0000269|PubMed:15958283, ECO:0000269|PubMed:19711341}.
|