PPP3CA

Gene Symbol PPP3CA
Entrez Gene 5530
Alt Symbol CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
Species Human
Gene Type protein-coding
Description protein phosphatase 3, catalytic subunit, alpha isozyme
Other Description CAM-PRP catalytic subunit|calcineurin A alpha|calmodulin-dependent calcineurin A subunit alpha isoform|protein phosphatase 2B, catalytic subunit, alpha isoform|protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform|serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Swissprots A1A441 A8W6Z8 B5BUA2 A8W6Z7 A8K3B7 Q8TAW9 Q08209
Accessions EAX06123 EAX06124 EAX06125 Q08209 AB451338 BAG70152 AB451487 BAG70301 AK290532 BAF83221 AL353950 CAB89253 AM393486 CAL38363 AM393713 CAL38589 AW973358 AY904364 AAY17314 BC025714 AAH25714 BC098424 EU192652 ABW74484 EU192653 ABW74485 J05480 AAA35634 L14778 AAA02631 NM_000944 NP_000935 NM_001130691 NP_001124163 NM_001130692 NP_001124164
Function Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. {ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:18838687}.
Subcellular Location Cell membrane {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.
Top Pathways Glucagon signaling pathway, Glutamatergic synapse, Dopaminergic synapse, Amphetamine addiction, Oxytocin signaling pathway

Pan-Calcineurin A Antibody - 2614 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of lysates from MCF7, NIH/3T3, C6 and COS cells, using Pan-Calcineurin A antibody.

PP2B-A (H-209) - sc-9070 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
PP2B-A (H-209): sc-9070. Western blot analysis of PP2B-A expression in mouse brain extract.

PP2B-Aα (C-20) - sc-6123 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
PP2B-Aα (C-20): sc-6123. Western blot analysis of PP2B-Aα expression in mouse brain extract.

PP2B-Aα (D-9) - sc-17808 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
PP2B-Aα (D-9): sc-17808. Immunofluorescence staining of methanol-fixed EOC 20 cells showing cytoplasmic localization.

Anti-Calcineurin A antibody - ab3673 from Abcam

Prices $398.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot of wild type mouse brain homogenate with ab3673 used at 1/6000. Please note that this image was assembled from two different blots. (The numbers on the scale correspond to kD).

Anti-Calcineurin A antibody - ab119298 from Abcam

Prices $384.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
ab119298, at 5µg/ml, staining Human Calcineurin A in small intestine, using Immunohistochemistry, Formalin/PFA-fixed paraffin-embedded tissue.

Anti-Calcineurin A antibody - ab55869 from Abcam

Prices $370.00
Sizes 100 µg
Host Chicken
Clonality Polyclonal

Anti-Calcineurin A antibody [EP1669Y] - ab52761 from Abcam

Prices $388.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1669Y
Anti-Calcineurin A antibody [EP1669Y] (ab52761) at 1/10000 dilution + Hela cell lysate at 10 µgSecondaryGoat anti-rabbit HRP labeled at 1/2000 dilution

Anti-Calcineurin A antibody [EPR1670(2)] - ab109412 from Abcam

Prices $385.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR1670(2)
Overlay histogram showing HeLa cells stained with ab109412 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab109412, 1/100 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H+L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-PPP3CA / CCN1 / Calcineurin A Antibody - LS-C121132 from LifeSpan Bioscience

Host Mouse
Clonality Monoclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody - LS-C121449 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (C-Terminus) - LS-C125230 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (aa1-50) - LS-C125229 from LifeSpan Bioscience

Prices $545.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody - LS-C125231 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody - LS-C127168 from LifeSpan Bioscience

Prices $465.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (clone 2G8) - LS-C133392 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G8

Anti-PPP3CA / CCN1 / Calcineurin A Antibody - LS-C140464 from LifeSpan Bioscience

Prices $330.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody - LS-C153115 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody - LS-C48178 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of CCN1 / Calcineurin A antibody LS-C48178.

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (clone CC-6) - LS-C171057 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CC-6

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (clone CC-6, Magnetic beads) - LS-C171058 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CC-6

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (clone CC-6, Sepharose) - LS-C171059 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone CC-6

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (N-Terminus) - LS-C81636 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
293T cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (aa364-283, Atto 390) - LS-C230414 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-PPP3CA / CCN1 / Calcineurin A Antibody (aa364-283, Atto 488) - LS-C230416 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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