| Gene Symbol |
PPP3CA
|
| Entrez Gene |
5530
|
| Alt Symbol |
CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
protein phosphatase 3, catalytic subunit, alpha isozyme
|
| Other Description |
CAM-PRP catalytic subunit|calcineurin A alpha|calmodulin-dependent calcineurin A subunit alpha isoform|protein phosphatase 2B, catalytic subunit, alpha isoform|protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform|serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
|
| Swissprots |
A1A441 A8W6Z8 B5BUA2 A8W6Z7 A8K3B7 Q8TAW9 Q08209
|
| Accessions |
EAX06123 EAX06124 EAX06125 Q08209 AB451338 BAG70152 AB451487 BAG70301 AK290532 BAF83221 AL353950 CAB89253 AM393486 CAL38363 AM393713 CAL38589 AW973358 AY904364 AAY17314 BC025714 AAH25714 BC098424 EU192652 ABW74484 EU192653 ABW74485 J05480 AAA35634 L14778 AAA02631 NM_000944 NP_000935 NM_001130691 NP_001124163 NM_001130692 NP_001124164
|
| Function |
Calcium-dependent, calmodulin-stimulated protein phosphatase. Many of the substrates contain a PxIxIT motif. This subunit may have a role in the calmodulin activation of calcineurin. Dephosphorylates DNM1L, HSPB1 and SSH1. {ECO:0000269|PubMed:15671020, ECO:0000269|PubMed:17498738, ECO:0000269|PubMed:18838687}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}. Cell membrane, sarcolemma {ECO:0000250}. Nucleus {ECO:0000250}. Note=Colocalizes with ACTN1 and MYOZ2 at the Z line in heart and skeletal muscle. {ECO:0000250}.
|
| Top Pathways |
Glucagon signaling pathway, Glutamatergic synapse, Dopaminergic synapse, Amphetamine addiction, Oxytocin signaling pathway
|