GRIN2B

Gene Symbol GRIN2B
Entrez Gene 2904
Alt Symbol EIEE27, GluN2B, MRD6, NMDAR2B, NR2B, hNR3
Species Human
Gene Type protein-coding
Description glutamate receptor, ionotropic, N-methyl D-aspartate 2B
Other Description N-methyl D-aspartate receptor subtype 2B|N-methyl-D-aspartate receptor subunit 3|NR3|glutamate [NMDA] receptor subunit epsilon-2|glutamate receptor ionotropic, NMDA 2B|glutamate receptor subunit epsilon-2
Swissprots Q12919 Q14CU4 Q13225 Q9UM56 Q13224 Q13220
Accessions EAW96311 Q13224 AB208850 BAD92087 AK091524 BC113618 AAI13619 BC113620 AAI13621 BX648060 U11287 AAB60368 U28758 AAA74930 U28861 AAA69919 U28862 AAA69920 U88963 AAD00659 U90278 AAB49993 XM_005253351 XP_005253408 XM_011520628 XP_011518930 XM_011520629 XP_011518931 XM_011520630 XP_011518932 NM_000834 NP_000825
Function NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine. In concert with DAPK1 at extrasynaptic sites, acts as a central mediator for stroke damage. Its phosphorylation at Ser-1303 by DAPK1 enhances synaptic NMDA receptor channel activity inducing injurious Ca2+ influx through them, resulting in an irreversible neuronal death (By similarity). {ECO:0000250}.
Subcellular Location Cell membrane; Multi-pass membrane protein. Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein.
Tissue Specificity Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia. {ECO:0000269|PubMed:9547169}.
Top Pathways Rap1 signaling pathway, Circadian entrainment, Alcoholism, Cocaine addiction, cAMP signaling pathway